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Drosophila melanogaster, maintained on culture media containing alpha-methyl-p-tyrosine (α-MT) at millimolar levels for 7 days, fail to produce viable progeny. Lesser concentrations delay development. This effect of α-MT, an inhibitor of tyrosine hydroxylase (TH), is partially reversible by co-administration of L-dihydroxyphenylalanine, the product of TH. Potent inhibitors of other steps in the...