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TGF‐β plays a central role in mediating epithelial–mesenchymal transition (EMT) by activating the Smad pathway. In addition, accumulating evidence suggests that TGF‐β‐induced EMT is NF‐κB‐dependent in various cancer types. However, it is largely unclear if NF‐κB mediates TGF‐β‐induced EMT in breast cancer, and if this mediation occurs, the regulatory mechanisms are unknown. In our study, we found...
Carcinoma-associated fibroblasts (CAFs) are abundant and heterogeneous stromal cells in tumor microenvironment that are critically involved in cancer progression. Here, we demonstrate that two cell-surface molecules, CD10 and GPR77, specifically define a CAF subset correlated with chemoresistance and poor survival in multiple cohorts of breast and lung cancer patients. CD10+GPR77+ CAFs promote tumor...
This paper presents a new on-line coal identification system based on support vector machine (SVM) to achieve on-line coal identification under variable combustion conditions. Four different coals were burnt in a 0.3MW coal combustion furnace with different coal feed rates, total air flow rates and flow rate ratios of primary air and secondary air. The flame monitoring system was installed at the...
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