Search results for: L. Myatt

Items from 1 to 20 out of 63 results

article

COLLECT, a collaborative database for pregnancy and placental research studies worldwide

JE Myers, L Myatt, JM Roberts, CWG Redman, more

BJOG: An International Journal of Obstetrics & Gynaecology > 126 > 1 > 8 - 10

article

IFPA meeting 2015 workshop report I: placental mitochondrial function, transport systems and epigenetics

T. Bianco-Miotto, C. Blundell, S. Buckberry, L. Chamley, more

Placenta > 2016 > 48 > S1 > S3-S6

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2015 there were twelve themed workshops, three of which are summarized in this report. These workshops covered areas of placental regulation and nutrient handling: 1) placental epigenetics; 2) placental mitochondrial function; 3) placental transport systems.

article

Starting Manufacture of the ITER Central Solenoid

P. Libeyre, C. Cormany, N. Dolgetta, E. Gaxiola, more

IEEE Transactions on Applied Superconductivity > 2016 > 26 > 4 > 1 - 5

The central solenoid (CS) is a key component of the ITER magnet system to provide the magnetic flux swing required to drive induced plasma current up to 15 MA. The manufacture of its different subcomponents has now started, following completion of the design analyses and achievement of the qualification of the manufacturing procedures. A comprehensive set of analyses has been produced to demonstrate...

article

Prenatal vitamin C and E supplementation in smokers is associated with reduced placental abruption and preterm birth: a secondary analysis

A Abramovici, RE Gandley, RG Clifton, KJ Leveno, more

BJOG: An International Journal of Obstetrics & Gynaecology > 122 > 13 > 1740 - 1747

ObjectiveSmoking and pre‐eclampsia (PE) are associated with increases in preterm birth, placental abruption and low birthweight. We evaluated the relationship between prenatal vitamin C and E (C/E) supplementation and perinatal outcomes by maternal self‐reported smoking status focusing on outcomes known to be impacted by maternal smoking. Design/Setting/PopulationA secondary analysis of a multi‐centre...

article

Sexual dimorphism in the effect of maternal obesity on placental mitochondrial function

L. Myatt, S. Muralimanoharan, A. Maloyan

Placenta > 2015 > 36 > 4 > 470-471

article

The anatomy and physiology of a manuscript

Yoel Sadovsky, L. Myatt, Graham Burton

Placenta > 2015 > 36 > 4 > 473

article

Roles of glucocorticoids in human parturition: A controversial fact?

X.Q. Li, P. Zhu, L. Myatt, K. Sun

Placenta > 2014 > 35 > 5 > 291-296

The pivotal role of glucocorticoids in the initiation of parturition has been very well documented in several domestic mammalian animal species. However the role of glucocorticoids in human parturition remains controversial mainly because of the absence of effect of synthetic glucocorticoids, given to promote fetal organ maturation in pregnant women with threatened preterm delivery, on the length...

article

Corrigendum to ‘Optimising sample collection for placental research’ [Placenta 35 (2014) 9–22]

G.J. Burton, N.J. Sebire, L. Myatt, D. Tannetta, more

Placenta > 2014 > 35 > 4 > 289

article

Moving Toward Manufacture of the ITER Central Solenoid

P. Libeyre, D. Bessette, N. Dolgetta, Y. Gribov, more

IEEE Transactions on Applied Superconductivity > 2014 > 24 > 3 > 1 - 5

After several years of design optimization, the Central Solenoid (CS) of the ITER Magnet system is now moving towards manufacture. The design has evolved to take into account on one hand the results of the R&D carried out by the US ITER team in charge of the development of the design and on the other hand the feedback provided by the involvement of industry in preparation of the manufacture. To...

article

Optimising sample collection for placental research

G.J. Burton, N.J. Sebire, L. Myatt, D. Tannetta, more

Placenta > 2014 > 35 > 1 > 9-22

Biobanks provide an important repository of samples for research purposes. However, for those samples to reflect the in vivo state, and for experimental reliability and reproducibility, careful attention to collection, processing and storage is essential. This is particularly true for the placenta, which is potentially subjected to stressful conditions during delivery, and sample collection may be...

article

Evidence of sexual dimorphism in the placental function with severe preeclampsia

S. Muralimanoharan, A. Maloyan, L. Myatt

Placenta > 2013 > 34 > 12 > 1183-1189

Preeclampsia (PE) affects 5–8% of pregnancies and is responsible for 18% of maternal deaths in the US, and for long-term complications in mother and child. PE is an inflammatory state and may influence placental function in a sex-specific manner. We determined if there is a sexual dimorphism in the placental inflammatory and apoptotic responses in preeclamptic pregnancies. Placentas were collected...

article

Can changes in angiogenic biomarkers between the first and second trimesters of pregnancy predict development of pre‐eclampsia in a low‐risk nulliparous patient population?

L Myatt, RG Clifton, JM Roberts, CY Spong, more

BJOG: An International Journal of Obstetrics & Gynaecology > 120 > 10 > 1183 - 1191

ObjectiveTo determine if change in maternal angiogenic biomarkers between the first and second trimesters predicts pre‐eclampsia in low‐risk nulliparous women. DesignA nested case–control study of change in maternal plasma soluble Flt‐1 (sFlt‐1), soluble endoglin (sEng) and placenta growth factor (PlGF). We studied 158 pregnancies complicated by pre‐eclampsia and 468 normotensive nonproteinuric controls...

chapter

ITER Central Solenoid design

D. Everitt, W. Reiersen, N. Martovetsky, R. Hussung, more

2013 IEEE 25th Symposium on Fusion Engineering (SOFE) > 1 - 8

2013 IEEE 25th Symposium on Fusion Engineering (SOFE)

The Central Solenoid (CS) is a critical component in the ITER tokamak providing plasma current drive and shaping. The CS final design is being completed at the US ITER Project Office (USIPO) in Oak Ridge, TN under a Procurement Arrangement with the ITER Organization (IO). Key design decisions have been made and CAD models and drawings developed. Interfaces have been established. An extensive R&D...

article

MIR-210 modulates mitochondrial respiration in placenta with preeclampsia

S. Muralimanoharan, A. Maloyan, J. Mele, C. Guo, more

Placenta > 2012 > 33 > 10 > 816-823

Preeclampsia (PE) affects 5–8% of all pregnancies and is associated with significant maternal and fetal morbidity and mortality. Placental mitochondrial dysfunction has been reported in PE. MicroRNAs (miRNA) are small non-coding RNAs that regulate gene expression through mRNA degradation and translational repression. MiR-210 has been previously shown to be upregulated in placentas from pregnancies...

article

Measurement of mitochondrial respiration in trophoblast culture

A. Maloyan, J. Mele, B. Muralimanohara, L. Myatt

Placenta > 2012 > 33 > 5 > 456-458

Pregnancy is a state of oxidative stress, which becomes exaggerated under pathological conditions, such as preeclampsia, IUGR, diabetes and obesity, where placental mitochondrial dysfunction is observed. The majority of investigations utilize isolated mitochondria when measuring mitochondrial activity in placenta. However, this does not provide a complete physiological readout of mitochondrial function...

article

Addressing the Technical Challenges for the Construction of the ITER Central Solenoid

P. Libeyre, D. Bessette, M. Jewell, C. Jong, more

IEEE Transactions on Applied Superconductivity > 2012 > 22 > 3 > 4201104

The Central Solenoid (CS) of the ITER Magnet system is split into six independently powered coils enclosed inside an external structure which provides vertical precompression thus preventing separation of the coils and acting as a support to net resulting loads. The analyses include an assessment of the mechanical behavior of the different components of the CS, under the normal and fault conditions,...

article

IFPA Meeting 2010 Workshop Report I: Immunology; Ion transport; Epigenetics; Vascular reactivity; Epitheliochorial placentation; Proteomics

C. Abad, D.F. Antczak, J. Carvalho, L.W. Chamley, more

Placenta > 2011 > 32 > Supplement 2 > S81-S89

Workshops are an important part of the IFPA annual meeting. At IFPA Meeting 2010 there were twelve themed workshops, six of which are summarized in this report. 1. The immunology workshop focused on normal and pathological functions of the maternal immune system in pregnancy. 2. The transport workshop dealt with regulation of ion and water transport across the syncytiotrophoblast of human placenta...

article

Placental Amino Acid Transport and Placental Leptin Resistance in Pregnancies Complicated by Maternal Obesity

D.M. Farley, J. Choi, D.J. Dudley, C. Li, more

Placenta > 2010 > 31 > 8 > 718-724

We hypothesized that maternal obesity is associated with increased placental amino acid transport and hyperleptinemia. Our objectives were to study placental amino acid transport and the effect of leptin on placental amino acid transport in vitro in the setting of maternal obesity.Seven lean, BMI at entry 22.4, and seven obese, BMI at entry 31.5 (p < 0.001), pregnant women were studied at 39 weeks...

article

Review: Reactive oxygen and nitrogen species and functional adaptation of the placenta

L. Myatt

Placenta > 2010 > 31 > Supplement > S66-S69

The placenta regulates fetal growth and development via transport of nutrients and gases, and synthesis and secretion of steroid and peptide hormones. These functions are determined by vascular development and blood flow and by growth and differentiation of the trophoblast, which contains receptors, transporters and enzymes. The placenta generates reactive oxygen species which may contribute to the...

article

Effect of Increasing Maternal Body Mass Index on Oxidative and Nitrative Stress in The Human Placenta

V.H.J. Roberts, J. Smith, S.A. McLea, A.B. Heizer, more

Placenta > 2009 > 30 > 2 > 169-175

Maternal obesity is an increasing problem in obstetrics associated with adverse pregnancy outcomes and delivery complications. As an inflammatory state, where elevated levels of pro-inflammatory cytokines are found, obesity can lead to the increased incidence of oxidative and nitrative stress. These stresses may result in protein oxidation and protein nitration respectively, which are post- translational...

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Search results for: L. Myatt

COLLECT, a collaborative database for pregnancy and placental research studies worldwide

IFPA meeting 2015 workshop report I: placental mitochondrial function, transport systems and epigenetics

Starting Manufacture of the ITER Central Solenoid

Prenatal vitamin C and E supplementation in smokers is associated with reduced placental abruption and preterm birth: a secondary analysis

Sexual dimorphism in the effect of maternal obesity on placental mitochondrial function

The anatomy and physiology of a manuscript

Roles of glucocorticoids in human parturition: A controversial fact?

Corrigendum to ‘Optimising sample collection for placental research’ [Placenta 35 (2014) 9–22]

Moving Toward Manufacture of the ITER Central Solenoid

Optimising sample collection for placental research

Evidence of sexual dimorphism in the placental function with severe preeclampsia

Can changes in angiogenic biomarkers between the first and second trimesters of pregnancy predict development of pre‐eclampsia in a low‐risk nulliparous patient population?

ITER Central Solenoid design

MIR-210 modulates mitochondrial respiration in placenta with preeclampsia

Measurement of mitochondrial respiration in trophoblast culture

Addressing the Technical Challenges for the Construction of the ITER Central Solenoid

IFPA Meeting 2010 Workshop Report I: Immunology; Ion transport; Epigenetics; Vascular reactivity; Epitheliochorial placentation; Proteomics

Placental Amino Acid Transport and Placental Leptin Resistance in Pregnancies Complicated by Maternal Obesity

Review: Reactive oxygen and nitrogen species and functional adaptation of the placenta

Effect of Increasing Maternal Body Mass Index on Oxidative and Nitrative Stress in The Human Placenta

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