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Objectives. This study sought to determine the effect of antioxidant supplementation on the susceptibility of low density lipoprotein (LDL) to oxidation in patients with established cardiovascular disease (CVD).Background. Data are inconsistent regarding the role of antioxidant nutrients in the prevention of CVD.Methods. The study design was a 12-week, double-blind, placebo-controlled clinical trial...
We studied the effect of a combination of vitamin E, vitamin C, and beta-carotene on the susceptibility of LDL to oxidation, as determined by lag phase (minutes), in a 12 week clinical trial of 45 patients with coronary artery disease (CAD), mean age 60.6 +/- 8.6 years. Subjects were randomized to one of the following interventions (15 each): 1) placebo; 2) vitamin E 400 IU, vitamin C 500 mg, beta-carotene...