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Romosozumab is a monoclonal antibody that inhibits sclerostin and has been shown to reduce the risk of fractures within 12 months. In a phase II, randomized, placebo‐controlled clinical trial of treatment‐naïve postmenopausal women with low bone mass, romosozumab increased bone mineral density (BMD) at the hip and spine by the dual effect of increasing bone formation and decreasing bone resorption...
High-power green LEDs in mass-production is reaching a new WPE (wall-plug-efficiency) level of 35%, and this progress results from both band- and strain-engineering in the active multiple-quantum-well region and optimal p- and n-electrodes layout for uniform current spreading. For high-power green LEDs of chip size 45 mil×45 mil (4545 chips), the forward voltage at 350 mA is as low as 2.8 V, with...
While higher associativities are common at L-2 or Last-Level cache hierarchies, direct-mapped and low associative caches are still used at L-1 level. Lower associativities result in higher miss rates, but have fast access times on hits. Another issue that inhibits cache performance is the non-uniformity of accesses exhibited by most applications: some sets are underutilized while others receive the...
In the spring of 2009, a novel strain of H1N1 swine-origin influenza A virus (S-OIV) emerged in Mexico and the United States, and soon after was declared a pandemic by the World Health Organization. This work examined the ability of real-time reports of influenza-like illness (ILI) symptoms and rapid influenza diagnostic tests (RIDTs) to approximate the spatiotemporal distribution of PCR-confirmed...
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