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A new screening method was developed for the detection of CAG expanded alleles in patients with hereditary ataxia using polymerase chain reaction-based microtiter plate hybridization (PCR-MPH). The system can be applied to detect pathologic alleles by hybridization with the immobilized (CAG) 48 repeat probe derived from the unrelated gene 'ERDA1' except for the CAG repeats. We examined...
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