Search results for: Keisuke Hamasaki

Items from 1 to 20 out of 25 results

article

Non‐liver‐related mortality in the DAA era: Insights from post‐SVR patients with and without previous HCC history

Satoshi Miuma, Hisamitsu Miyaaki, Tatsuki Ichikawa, Toshihisa Matsuzaki, more

Journal of Medical Virology > 96 > 3 > n/a - n/a

Background and Aims Mortality after sustained virological response (SVR) with interferon‐free direct‐acting antiviral (IFN‐free DAA) therapy is crucial for optimizing post‐SVR patient care, but it remains unclear, especially regarding non‐liver‐related mortality. Methods Consecutive post‐SVR patients from 14 institutions were stratified into three cohorts: A (without advanced fibrosis and without...

article

Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis

Mariko Kusaba, Kazuhiko Nakao, Takashi Goto, Daisuke Nishimura, more

Journal of Hepatology > 2007 > 47 > 4 > 546-555

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated and regulates cell growth and survival of various cancer cells. We investigated the anti-tumor effect of AG490, a Janus kinase 2 specific inhibitor, inhuman hepatoma cells.Effects of AG490 on STAT3 activation, on cell-growth and survival, and on the expression of cell-cycle- and apoptosis-related proteins were evaluated...

article

Role of growth hormone, insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in development of non-alcoholic fatty liver disease

Tatsuki Ichikawa, Kazuhiko Nakao, Keisuke Hamasaki, Ryuji Furukawa, more

Hepatology International > 2007 > 1 > 2 > 287-294

Background and aims Pituitary dysfunction including growth hormone (GH) deficiency may be associated with non-alcoholic fatty liver disease (NAFLD). Since the relationships among GH, IGF-1, IGFBP-3, and development of NAFLD without hypopituitarism are unclear, we examined the role of these hormones in the development of NAFLD based on clinical, laboratory and liver histology data. Patients and methods...

article

The Impact of Newer Treatment Modalities on Survival in Patients With Hepatocellular Carcinoma

Naota Taura, Keisuke Hamasaki, Kazuhiko Nakao, Tatsuki Ichikawa, more

Clinical Gastroenterology and Hepatology > 2006 > 4 > 9 > 1177-1183

Background & Aims: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. However, although the therapeutic approaches for HCC have progressed rapidly, it remains unknown whether the current management of patients with HCC has reduced its mortality. We analyzed changes of survival rate in patients with HCC over a 20-year period. Methods: Between 1982 and 2001, 463 patients...

article

Increasing hepatitis C virus-associated hepatocellular carcinoma mortality and aging: Long term trends in Japan

Naota Taura, Hiroshi Yatsuhashi, Keisuke Hamasaki, Kazuhiko Nakao, more

Hepatology Research > 2006 > 34 > 2 > 130-134

The incidence of hepatocellular carcinoma (HCC) in Japan has been increasing. The aim of the study was to determine the epidemiological trends in HCC mortality in Japan.We reviewed the medical records of all patients whose death was caused by liver disease between 1981 and 2000 at two hospitals. The courses of death were separated based on presence or absence of HCC when death ensued. Additionally,...

article

Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection—association between TGF-β1 polymorphisms and hepatocellular carcinoma

Kiyoshi Migita, Seiji Miyazoe, Yumi Maeda, Manabu Daikoku, more

Journal of Hepatology > 2005 > 42 > 4 > 505-510

In this study, we determined the frequencies of the genotypes associated with the polymorphism of the cytokines genes, and investigated their association with the risk of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) carriers.Genetic polymorphism in the cytokines TNF-α, IFN-γ, TGF-β1, IL-6, and IL-10 were studied in 236 Japanese patients with HBV infection. The genetic polymorphisms of...

article

Interferon alpha inhibits the nuclear factor kappa B activation triggered by X gene product of hepatitis B virus in human hepatoma cells

Kazuyuki Ohata, Tatsuki Ichikawa, Kazuhiko Nakao, Masaya Shigeno, more

FEBS Letters > 2003 > 553 > 3 > 304-308

X gene product of hepatitis B virus (HBV) (HBx) regulates many transcription factors including nuclear factor kappa B (NF-κB) and plays a key role in hepatocarcinogenesis. In this study, we demonstrated that the expression of full HBV genome and HBx gene similarly stimulated the transcriptional activity of NF-κB in HuH-7 human hepatoma cells, and that interferon (IFN)-α as well as dominant negative...

article

Analysis of anti-HBs levels in healthcare workers over 10 years following booster vaccination for hepatitis B virus

Kazuhiko Nakao, Keisuke Hamasaki, Naoko Wakihama, Mayumi Maeda, more

Vaccine > 2003 > 21 > 25-26 > 3789-3794

In this study, we analyzed anti-HBs levels in 104 Japanese healthcare workers who received three booster HBV surface antigen (HBsAg) vaccines because 80 became anti-HBs-negative at a mean of 2.4 years after the primary vaccination and 24 did not respond to primary vaccination. Of the re-vaccinees, 96% achieved a level of 10mIU/ml or more of anti-HBs (i.e. seroprotected), 1 month after booster vaccination...

article

Short interfering RNA-directed inhibition of hepatitis B virus replication

Keisuke Hamasaki, Kazuhiko Nakao, Kojiro Matsumoto, Tatsuki Ichikawa, more

FEBS Letters > 2003 > 543 > 1-3 > 51-54

RNA interference (RNAi) is the process by which double-stranded RNA directs sequence-specific degradation of mRNA. In mammalian cells, RNAi can be triggered by 21-nucleotide duplexes of short interfering RNA (siRNA). We examined effects of siRNA on hepatitis B virus (HBV) replication. Human hepatoma cells were transfected with HBV DNA and siRNA against HBV-pregenome RNA. Transfection experiments demonstrated...

article

Antiangiogenic gene therapy for hepatocellular carcinoma using angiostatin gene

Hiroki Ishikawa, Kazuhiko Nakao, Kojiro Matsumoto, Tatsuki Ichikawa, more

Hepatology > 2003 > 37 > 3 > 696-704

Recent studies have reported that antiangiogenic gene delivery into cancer cells inhibits growth of certain tumors in vivo. Hepatocellular carcinoma (HCC) is a hypervascular cancer, and antiangiogenic gene therapy might be suitable for HCC. In the present study, we investigated the antiangiogenic effects of angiostatin gene transduction into HCC both in vitro and in vivo. Angiostatin gene was cloned...

article

p48 Overexpression enhances interferon-mediated expression and activity of double-stranded RNA-dependent protein kinase in human hepatoma cells

Yoko Tamada, Kazuhiko Nakao, Yuji Nagayama, Keisuke Nakata, more

Journal of Hepatology > 2002 > 37 > 4 > 493-499

Background/Aims: Double-stranded RNA-dependent protein kinase (PKR) is a key factor involved in interferon (IFN)-induced antiviral actions. Since p48, together with signal transducers and activators of transcription 1 and 2 (STAT1 and STAT2), is an indispensable mediator in IFN-α signaling pathways, we investigated the effect of p48 gene transduction on PKR expression and its activity in HuH-7 human...

article

Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus

Seiji Miyazoe, Keisuke Hamasaki, Keisuke Nakata, Yuji Kajiya, more

The American Journal of Gastroenterology > 2002 > 97 > 8 > 2086-2092

OBJECTIVES:The role of host genetic factors in chronic hepatitis B virus (HBV) infection is not fully understood. We studied the influence of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) gene promoter polymorphisms on disease progression in HBV carriers.METHODS:The sample population included 213 Japanese HBV carriers and 52 healthy volunteers. Of 213 HBV carriers, 66 were considered...

article

Association between nonalcoholic fatty liver, markers of obesity, and serum leptin level in young adults

Kazuhiko Nakao, Keisuke Nakata, Noriko Ohtsubo, Mayumi Maeda, more

The American Journal of Gastroenterology > 2002 > 97 > 7 > 1796-1801

OBJECTIVES:The aim of the present study was to clarify the risk factors for nonalcoholic fatty liver in young adults.METHODS:One thousand two hundred two students, aged 18-21 yr, received matriculation health examinations, including measurements of body mass index and percent body fat and determination of serum levels of ALT at Nagasaki University in 1998. One hundred twenty-nine were found to have...

article

Involvement of IL-1β and IL-10 in IFN-α-mediated antiviral gene induction in human hepatoma cells

Tatsuki Ichikawa, Kazuhiko Nakao, Keisuke Nakata, Mayumi Yamashita, more

Biochemical and Biophysical Research Communications > 2002 > 294 > 2 > 414-422

Crosstalk between interferons (IFNs) and several cytokines is likely to play an important role in viral clearance in chronic hepatitides B and C. We investigated the influence of this phenomenon on IFN-inducible antiviral gene expression in HuH-7 human hepatoma cells. HuH-7 cells were treated with IFN-α in the absence or presence of interleukin-1β (IL-1β) or IL-10 and the expression of antiviral genes...

article

Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells

Seigou Abiru, Kazuhiko Nakao, Tatsuki Ichikawa, Kiyoshi Migita, more

Hepatology > 2002 > 35 > 5 > 1117-1124

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity and are considered to exert antitumor actions in a variety of cancer cells, although the effects are unlikely entirely due to COX inhibition. Because clinical observations suggest that hepatocyte growth factor (HGF) can promote metastasis of hepatoma cells while stimulating tumor invasiveness, we investigated the effect...

article

Spontaneous regression of hepatocellular carcinoma associated with elevated levels of interleukin 18

Seigou Abiru, Yuji Kato, Keisuke Hamasaki, Kazuhiko Nakao, more

The American Journal of Gastroenterology > 2002 > 97 > 3 > 774-775

article

Geranylgeranylacetone Induces Antiviral Gene Expression in Human Hepatoma Cells

Tatsuki Ichikawa, Kazuhiko Nakao, Keisuke Nakata, Keisuke Hamasaki, more

Biochemical and Biophysical Research Communications > 2001 > 280 > 3 > 933-939

Geranylgeranylacetone (GGA), an isoprenoid compound, is used clinically as an anti-ulcer drug. Since some isoprenoids including retinoids have anti-tumor and anti-viral activities in a variety of cell types, we investigated whether GGA could induce anti-viral proteins in human hepatoma cells. The HuH-7 and HepG2 cells were treated with GGA, and expression of anti-viral proteins such as 2'5'-oligoadenylate...

article

A Long-Term Follow-Up Analysis of Serial Core Promoter and Precore Sequences in Japanese Patients Chronically Infected by Hepatitis B Virus

Yuji Kajiya, Keisuke Hamasaki, Keisuke Nakata, Seiji Miyazoe, more

Digestive Diseases and Sciences > 2001 > 46 > 3 > 509-515

To investigate the association of hepatitis B virus (HBV) with core promoter mutation (T¹⁷⁶²A¹⁷⁶⁴) or precore mutation (A¹⁸⁹⁶) with the clinical course of illness, we analyzed serial core promoter and precore sequences in 22 patients with HBV-associated chronic liver disease who were followed for 12 ± 4 years (mean ± sd). Sixteen of 22 patients were positive for HBeAg at baseline, and 15 of the 16...

article

Effects of naturally occurring mutations in hepatitis B virus core promoter on transcriptional activity

Keisuke Hamasaki, Manabu Daikoku, Yuji Kajiya, Kazuhiko Nakao, more

Hepatology Research > 2000 > 16 > 2 > 163 - 169

Hepatitis B virus (HBV) with mutations in the core promoter is thought to be selected naturally during chronic infection. In this study, effects of naturally occurring mutations in the HBV core promoter on transcriptional activity are anlayzed. To evaluate whether mutations in the core promoter affect transcriptional activity, chloramphenicol acetyltransferase (CAT) assay was performed. When CAT plasmids...

article

Spontaneous loss of hepatitis B surface antigen in chronic carriers, based on a long-term follow-up study in Goto Islands, Japan

Yuji Kato, Kazuhiko Nakao, Keisuke Hamasaki, Hiroyuki Kato, more

Journal of Gastroenterology > 2000 > 35 > 3 > 201-205

Abstract: Annual mass examination was performed between 1972 and 1997 in Tomie-town, Goto Islands, Japan, where hepatitis B virus (HBV) infection is very prevalent. In the present study, the incidence of spontaneous loss of hepatitis B surface antigen (HBsAg) in HBsAg carriers was determined in this area. Three thousand and nineteen inhabitants were tested for HBsAg two or more times in our annual...

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INFONA - science communication portal

Search results for: Keisuke Hamasaki

Non‐liver‐related mortality in the DAA era: Insights from post‐SVR patients with and without previous HCC history

Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis

Role of growth hormone, insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in development of non-alcoholic fatty liver disease

The Impact of Newer Treatment Modalities on Survival in Patients With Hepatocellular Carcinoma

Increasing hepatitis C virus-associated hepatocellular carcinoma mortality and aging: Long term trends in Japan

Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection—association between TGF-β1 polymorphisms and hepatocellular carcinoma

Interferon alpha inhibits the nuclear factor kappa B activation triggered by X gene product of hepatitis B virus in human hepatoma cells

Analysis of anti-HBs levels in healthcare workers over 10 years following booster vaccination for hepatitis B virus

Short interfering RNA-directed inhibition of hepatitis B virus replication

Antiangiogenic gene therapy for hepatocellular carcinoma using angiostatin gene

p48 Overexpression enhances interferon-mediated expression and activity of double-stranded RNA-dependent protein kinase in human hepatoma cells

Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus

Association between nonalcoholic fatty liver, markers of obesity, and serum leptin level in young adults

Involvement of IL-1β and IL-10 in IFN-α-mediated antiviral gene induction in human hepatoma cells

Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells

Spontaneous regression of hepatocellular carcinoma associated with elevated levels of interleukin 18

Geranylgeranylacetone Induces Antiviral Gene Expression in Human Hepatoma Cells

A Long-Term Follow-Up Analysis of Serial Core Promoter and Precore Sequences in Japanese Patients Chronically Infected by Hepatitis B Virus

Effects of naturally occurring mutations in hepatitis B virus core promoter on transcriptional activity

Spontaneous loss of hepatitis B surface antigen in chronic carriers, based on a long-term follow-up study in Goto Islands, Japan

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