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Intravascular ultrasound (IVUS) is a well-established diagnostic method that has been applied frequently for providing high-resolution images of vessel wall and atherosclerotic plaques. Side looking transducer has been employed in a catheter for delineating the structure of vessel wall and lesions. However, it is difficult to get the flow distribution in the vessel by side looking transducer as the...
High-frequency ultrasound (>20 MHz) imaging has gained widespread attention due to its high spatial resolution being useful for basic cardiovascular and cancer research involving small animals. The sampling rate of the analog-to-digital converter in a high-frequency ultrasound system usually needs to be higher than 120-MHz to satisfy the Nyquist requirement. However, the sampling rate is typically...
The acoustic microstreaming originating from microbubbles' linear oscillations can be used as a potential cell sonoporation tool for drug delivery and gene transfection. However, this bubble-based method suffers from bubble instability, non-uniform size, unreliable performance, and inconvenient trapping. In order to overcome the above drawbacks, in this study, we proposed a massive drug delivery method...
Invasiveness research is an essential step in breast cancer metastasis. The application of non-contact high frequency ultrasound microbeam stimulation (HFUMS) offers a manner of determining the invasion potential of breast cancer cells. In this article, we compare the calcium elevations elicited in breast cancer cells.
It is crucial to transport foreign substance into living cells efficiently and minimize adverse side-effects. Using ultrasound microbubble, it is possible to enhance the cellular uptake and transfer the extracellular molecules into cells, this process is called sonoporation. However, the spatial location of microbubbles appears to be a stochastic process, which makes the targeted sonoporation at specific...
Transcranial ultrasound is an emerging technology for non-surgical stimulation of the animal and human brain. Previous studies has demonstrated that ultrasound could elicit discharge activity of retinal cells with short latency in animal (Journal of Neuroscience 33(10):4550–4560, 2013) and enhances sensory discrimination abilities of somato-sensory cortex in humans (Nature Neuroscience 17(2):322–9,...
Acoustic lenses, concentrating the acoustic energy into a specific area, have attracted interest due to their broad applications in various domains, such as biomedical imaging, nondestructive testing, etc. For waterborne sound, conventional silicone materials are fabricated with concave shape for focusing wave. However, it is not flexible to design a concave lens than a flat lens to manipulate acoustic...
Nanoparticle manipulation has a variety of potential applications, from two-dimensional material fabrication to biomedical engineering. Pattern and transportation of nanoparticles has been receiving increasing attention in recent years. Ultrasound as a mechanical wave has proven to be the most effective in the manipulation of micro-objects in a non-contact and non-invasive fashion. However, due to...
We numerically report a high efficient acoustic lens using a flat artificial composite plate in water, which is designed using silicone films deposited on PMMA plate engraved with the annular grooves. The focusing effect is due to the phase of the plate changing with the height of PMMA variation, while the total height of the plate is held constant. As both PMMA and silicone are low impedance mismatch...
Ultrasound (US) brain stimulation has been demonstrated to be a promising approach for noninvasive neuromodulation. However, traditional methods always demand animals to be under anesthesia and body constraint to achieve stable operation with bulky US transducer, while those demands would result in interference to the neural activity related to perception, cognition, and behavior. Appling a miniature...
Recent studies have proven that ultrasound as a non-invasive method enable to delivery energy to deep brain for both excitation and reversible suppression of neuronal activity in cell, animal, human experiments (Scientific Reports 6:24170, 2016; Neuron 66(5):681-694; Nature Neuroscience 17(2):322-9, 2014). Due to bulk ultrasound transducer, it is difficult to compatible the ultrasound stimulation...
Intravascular ultrasound (IVUS) is a well-established diagnostic method that provides high-resolution images of vessel walls and atherosclerotic plaques. High-frequency (>50 MHz) ultrasound enables the spatial resolution of IVUS to approach that of optical imaging methods. However, the penetration depth decreases when using higher imaging frequencies due to the greater acoustic attenuation. In...
How to precisely evaluate the characteristics of glioma tumor in vivo is a challenging question for surgical resection clinically. Due to the infiltration feature of the tumor, precise resection remains challenging because of the uncertainties of surrounding vasculature. The sensitivity of flow measurement is improved by ultrafast plane-wave imaging which is capable of delineating the flow information...
Externally controlled drug release from nanoscale drug delivery systems hold great potential to increase local deposit. Here, we introduce an ultrasound-activatable porphyrin-phospholipid liposome (PPL) to show its controllable drug release, enhanced imaging signals, and efficient therapeutic actions.
More and more researches are exploring the neurostimulation effect of ultrasound (US) on the central nervous system (e.g. brain and retina) and the peripheral nervous system (such as skin). US stimulation has been regarded as a new noninvasive neurostimulation approach by many researchers. Our previous studies had shown that the temporal response patterns of RGCs could be stimulated by US in vitro...
Invasiveness research is an essential step in breast cancer metastasis. The application of high-frequency ultrasound microbeam stimulation (HFUMS) offers a manner of determining the invasion potential of human breast cancer cells by eliciting the elevation of transient cytoplasmic calcium ions (Ca2+). The fluorescent change in invasive breast cancer cells (MDA-MB-231), reflecting Ca2+ elevation elicited...
Enhancing the cell's membrane permeability enables to promote foreign substance into the cell and has various applications in biomedical engineering. Sonoporation employs the microbubble inertial cavitation to induce reversible cell-pores in the membranes allowing some impermeable molecules to be transferred into cells. However, the inertial cavitation is the violent collapse of bubbles and thus sonoporation...
Currently, intravascular ultrasound (IVUS) has been frequently used for diagnosing the atherosclerotic plaque due to its good imaging penetration and accurate evaluation. In general, two types of transducers were used for IVUS imaging, i.e. single-element transducer and radial array transducer. It should be noted that imaging resolution of single-element transducer was reduced in the deep area. In...
Atherosclerotic plaque rupture will cause acute coronary syndrome and sudden cardiac death, so that the diagnosis of this kind disease is crucial in clinical studies. Intravascular ultrasound (IVUS) imaging is an effective means of detecting atherosclerotic plaques. In general, two kinds of transducers were used for IVUS imaging, i.e. single-element transducer and radial array transducer. It should...
Ultrasound (US) brain stimulation has been demonstrated to be a promising approach for noninvasive neuromodulation. However, traditional methods always demand animals to be under anesthesia and body constraint to achieve stable operation with bulky US transducer, while those demands would result in interference to the neural activity related to perception, cognition, and behavior. Appling a miniature...
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