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CD59a is the primary regulator of membrane attack complex in mice. Recently, we have shown that CD59a-deficient (Cd59a −/− ) mice exhibit enhanced CD4 + T cell responses. Here, we explored the effects of CD59a on B cell function and antibody production. Contrary to our expectations, Cd59a −/− mice showed a decreased humoral immune response to a T cell dependent antigen, sheep...
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