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Leukotriene C 4 synthase (LTC 4 S) is considered a pivotal enzyme for generation of potent proinflammatory mediators, cysteinyl-leukotrienes (cysLTs). LTC 4 S cDNA was cloned in rat basophilic leukemia-1 (RBL-1) cells, and exhibited 84.8% and 94.5% identity with the reported human and mouse LTC 4 S cDNA sequences, respectively. Homology between the rat LTC 4 ...