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A serogroup B meningococcal outer membrane vesicle (OMV) vaccine was delivered either intranasally or intramuscularly to 12 and 10 volunteers, respectively. The mucosal vaccine was given as four weekly doses followed by a fifth dose after 5 months; each dose consisted of OMVs equivalent to 250μg of protein. The intramuscular (i.m.) vaccine, consisting of the same OMVs but adsorbed to Al(OH) 3...
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