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Genetic similarities between patients from the United States and South African (SA) Addison's Disease (AD) strengthen evidence for genetic association. SA‐AD (n = 73), SA healthy controls (N = 78), and US‐AD patients (N = 83) were genotyped for DQA1, DQB1, DRB1, and HLA‐B alleles. Serum was tested for the quantity of 21OH‐AA and IFNα‐AA at the Barbara Davis Center. Although not as profound as in US‐AD,...
Although the role of CD14 in recognizing Mycobacterium tuberculosis is well‐understood, the possible role of polymorphisms in susceptibility to develop tuberculosis remains unclear. This study evaluates whether there is an association of polymorphisms within the promoter of the CD14 gene with susceptibility to pulmonary tuberculosis. In a case–control study, we genotyped the eight known single nucleotide...
Preeclampsia (PE), especially severe PE including early (before 34 weeks' gestation) and late (after 34 weeks' gestation) onset PE, is one of the leading causes of maternal and fetal mortality and morbidity. It is well known that abnormal human leukocyte antigen subtype G (HLA‐G) expression may contribute to PE. In this study, we investigated allelic and genotypic frequencies of the 14 bp deletion/insert...
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