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This work reports the development of a porous microfluidic system which can serve as an in vitro model of natural vessels in circulatory and respiratory systems. The model possesses both structural and mechanical characteristics of the natural counterparts. To mimic the semi-permeable wall of natural vessels, microfluidic channels with porous walls are fabricated by spinning polymeric nanofibers on...
Blood viscosity is an important hematological parameter which is widely used for the diagnosis of atherosclerosis, thrombosis and stroke. Currently used Couette rheometer drives the blood flow at a certain shear rate and measures the viscosity from the resistance toque towards the rotational shaft. Although effective, conventional rheometer is limited due to the complex configuration and the relatively...
This paper describes reversible EWOD (electrowetting on dielectric) contact angle changes (~ 25deg) in sessile droplets and linear transportation of droplets on micro filter meshes, not flat solid surfaces. A key achievement is that droplets are manipulated on highly opened micro filter meshes (the opening ratio defined by the ratio of area of holes to total mesh area is over ~ 50%). A possible application...
This paper reports the use of a microchip containing microfabricated electrode arrays for investigation of in vitro differentiation process of skeletal myoblasts. The microelectrodes array was designed and fabricated to generate controllable electric fields to skeletal myoblasts during their proliferation and differentiation processes. The results showed that the electric signals with low amplitude...
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