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Quinine increases the conductance of hemi-gap junctions in horizontal cells. We investigated the mechanisms of alkalinization and the hypothesis that quinine-induced alkalinization produced these conductance increases. We found that quinine-induced alkalinizations were not blocked by cobalt, amiloridie, or DIDS. Therefore, this suggests that the alkalinization is not likely due to net proton flux...
Recent studies have revealed that excitation of specific nerve pathways can produce localized changes of pH in nervous tissue. It is important to determine both how these pH changes are generated and, even more importantly, how the excitability of neurons in the localized areas are affected. Evidence indicates that activation of both γ-aminobutyric acid (GABA) and l-glutamate receptor channels in...
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