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Background: To simplify the diagnostic strategy of patients suspected for venous thromboembolism, the use of D-dimer tests has been advocated. Very important for the safety of such diagnostic strategies would be the capacity to recognise false-normal D-dimer results, in order to prevent inadequately withholding anticoagulant treatment in patients who actually have the disease. Insight in the causes...
Factor V Arg → Gln 506 mutation is the most common, recently discovered genetic defect leading to an increased risk of venous thromboembolism. The factor V Arg → Gln 506 mutation causes resistance of coagulation factor V to activated protein C. The inheritance pattern of the factor V Arg → Gln 506 mutation is autosomal dominant. We investigated...
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