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Endothelial dysfunction occurs in hypoxia-related states such as ischemic heart disease or heart surgery. Intermediate- and small-conductance calcium-activated potassium channels (IK Ca and SK Ca ) are closely related to endothelium-dependent hyperpolarizing factor–mediated endothelial function. However, the status of these K Ca under hypoxia is unknown. We investigated whether...
We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (−605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis...
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