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AbstractIn order to characterize the gene encoding the ligand binding (1st; ) chain of the human IFN- receptor, two overlapping cosmid clones were analyzed. The gene spans over 25 kilobases (kb) of the genomic DNA and has seven exons. The extracellular domain is encoded by exons 1 to 5 and by part of exon 6. The transmembrane region is also encoded by exon 6. Exon 7 encodes the intracellular domain...
A unique glutamic acid-rich protein was previously identified in bovine rod photoreceptors (Sugimoto et al., 1991, Proc. Natl. Acad. Sci. USA 88:3116-31191) and later suggested to be a third subunit (γ) of the rod cGMP-gated cation channel (Chen et al., 1994, Proc. Natl. Acad. Sci. USA 91:11757-117611. Here, we report on the characterization of the GAR1 gene encoding a human homolog of bovine γ. Sequence...
In the course of our studies concerning the tissue-specific expression of the c-myb proto-oncogene, we have established the nucleotide sequence of the chicken c-myb 3'-proximal coding exons. In situ hybridization performed with different genomic DNA probes corresponding to nearly all the c-myb gene allowed us to localize the corresponding locus on the large acrocentric chromosome 3 in chicken. Our...
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