Wyniki wyszukiwania dla: Nilima Biswas

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artykuł

Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system

Nilima Biswas, Adam X. Maihofer, Saiful Anam Mir, Fangwen Rao, więcej

BMC Medical Genetics > 2016 > 17 > 1 > 1-11

Background Plasma coagulation Factor XIIa (Hageman factor; encoded by F12) and kallikrein (KAL or Fletcher factor; encoded by KLKB1) are proteases of the kallikerin-kinin system involved in converting the inactive circulating prorenin to renin. Renin is a key enzyme in the formation of angiotensin II, which regulates blood pressure, fluid and electrolyte balance and is a biomarker for cardiovascular,...

artykuł

Chromogranin B: intra‐ and extra‐cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms

Kuixing Zhang, Nilima Biswas, Jiaur R. Gayen, Jose Pablo Miramontes‐Gonzalez, więcej

Journal of Neurochemistry > 129 > 1 > 48 - 59

Chromogranin B (CHGB) is the major matrix protein in human catecholamine storage vesicles. CHGB genetic variation alters catecholamine secretion and blood pressure. Here, effective Chgb protein under‐expression was achieved by siRNA in PC12 cells, resulting in ~ 48% fewer secretory granules on electron microscopy, diminished capacity for catecholamine uptake (by ~ 79%), and a ~ 73% decline in stores...

artykuł

Genetic variation at the delta‐sarcoglycan (SGCD) locus elevates heritable sympathetic nerve activity in human twin pairs

C. Makena Hightower, Kuixing Zhang, José P. Miramontes‐González, Fangwen Rao, więcej

Journal of Neurochemistry > 127 > 6 > 750 - 761

The Syrian Cardiomyopathic Hamster (BIO‐14.6/53.58 strains) model of cardiac failure, resulting from naturally occurring deletion at the SGCD (delta‐sarcoglycan) locus, displays widespread disturbances in catecholamine metabolism. Rare Mendelian myopathy disorders of human SGCD occur, although common naturally occurring SGCD genetic variation has not been evaluated for effects on human norepinephrine...

artykuł

Development of a pharmacophore model for the catecholamine release-inhibitory peptide catestatin: Virtual screening and functional testing identify novel small molecule therapeutics of hypertension

Igor F. Tsigelny, Valentina L. Kouznetsova, Nilima Biswas, Sushil K. Mahata, więcej

Bioorganic & Medicinal Chemistry > 2013 > 21 > 18 > 5855-5869

The endogenous catecholamine release-inhibitory peptide catestatin (CST) regulates events leading to hypertension and cardiovascular disease. Earlier we studied the structure of CST by NMR, molecular modeling, and amino acid scanning mutagenesis. That structure has now been exploited for elucidation of interface pharmacophores that mediate binding of CST to its target, with consequent secretory inhibition...

artykuł

Neuropeptide Y (NPY)

Kuixing Zhang, Fangwen Rao, Jose Pablo Miramontes-Gonzalez, C. Makena Hightower, więcej

Journal of the American College of Cardiology > 2012 > 60 > 17 > 1678-1689

This study sought to understand whether genetic variation at the Neuropeptide Y (NPY) locus governs secretion and stress responses in vivo as well as NPY gene expression in sympathochromaffin cells. The NPY is a potent pressor peptide co-released with catecholamines during stress by sympathetic axons. Genome-wide linkage on NPY secretion identified a LOD (logarithm of the odds ratio) peak spanning...

artykuł

Catecholamine Storage Vesicles: Role of Core Protein Genetic Polymorphisms in Hypertension

Kuixing Zhang, Yuqing Chen, Gen Wen, Manjula Mahata, więcej

Current Hypertension Reports > 2011 > 13 > 1 > 36-45

Hypertension is a complex trait with deranged autonomic control of the circulation. The sympathoadrenal system exerts minute-to-minute control over cardiac output and vascular tone. Catecholamine storage vesicles (or chromaffin granules) of the adrenal medulla contain remarkably high concentrations of chromogranins/secretogranins (or “granins”), catecholamines, neuropeptide Y, adenosine triphosphate...

artykuł

Naturally Occurring Genetic Variants in Human Chromogranin A (CHGA) Associated with Hypertension as well as Hypertensive Renal Disease

Yuqing Chen, Fangwen Rao, Gen Wen, Jiaur R. Gayen, więcej

Cellular and Molecular Neurobiology > 2010 > 30 > 8 > 1395-1400

Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules. Changes in storage and release of CHGA in clinical and experimental hypertension prompted us to study whether genetic variation at the CHGA locus might contribute to alterations in autonomic function, and hence hypertension and its target organ consequences such as hypertensive renal disease (nephrosclerosis)...

artykuł

Chromogranin/secretogranin proteins in murine heart: myocardial production of chromogranin A fragment catestatin (Chga_364–384)

Nilima Biswas, Erica Curello, Daniel T. O’Connor, Sushil K. Mahata

Cell and Tissue Research > 2010 > 342 > 3 > 353-361

In the heart, the secretory granules containing the atrial natriuretic peptides (ANP) and B-type myocardial natriuretic peptide (BNP) provide the basis for the endocrine function of this organ. We sought to determine whether atrial and myocardial secretory granules contain chromogranin/secretogranin proteins including chromogranin A (CHGA/Chga), chromogranin B (CHGB/Chgb) and secretogranin II (SCG2/Scg2)...

artykuł

Biogenesis of the Secretory Granule: Chromogranin A Coiled-Coil Structure Results in Unusual Physical Properties and Suggests a Mechanism for Granule Core Condensation ^†

Coleman A. Mosley, Laurent Taupenot, Nilima Biswas, Joseph P. Taulane, więcej

Biochemistry > 2007 > 46 > 38 > 10999 - 11012

artykuł

Characterisation of an acid trehalase of Saccharomyces cerevisiae present in trehalase-sucrase aggregate

Nilima Biswas, Anil Kumar Ghosh

BBA - General Subjects > 1996 > 1290 > 1 > 95-100

An acid trehalase-sucrase aggregate was purified (by 780-fold) from Saccharomyces cerevisiae, following conventional protein purification techniques, to an apparent yield of 18.5%. The aggregate was electrophoretically homogeneous but contained 175, 90, 68, 60, 40 molar mass (kDa) bands on SDS-electrophoresis. The purified aggregate had a specific activity (acid trehalase) of 22 U/mg; aK _m ...

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