Search results for: Sushil K. Mahata

Items from 1 to 20 out of 47 results

article

Catestatin induces glycogenesis by stimulating the phosphoinositide 3‐kinase‐AKT pathway

Gautam Bandyopadhyay, Kechun Tang, Nicholas J. G. Webster, Geert Bogaart, more

Aim Defects in hepatic glycogen synthesis contribute to post‐prandial hyperglycaemia in type 2 diabetic patients. Chromogranin A (CgA) peptide Catestatin (CST: hCgA_352‐372) improves glucose tolerance in insulin‐resistant mice. Here, we seek to determine whether CST induces hepatic glycogen synthesis. Methods We determined liver glycogen, glucose‐6‐phosphate (G6P), uridine diphosphate glucose (UDPG)...

article

Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides

Elke M. Muntjewerff, Kechun Tang, Lisanne Lutter, Gustaf Christoffersson, more

Acta Physiologica > 232 > 2 > n/a - n/a

Aim A “leaky” gut barrier has been implicated in the initiation and progression of a multitude of diseases, for example, inflammatory bowel disease (IBD), irritable bowel syndrome and celiac disease. Here we show how pro‐hormone Chromogranin A (CgA), produced by the enteroendocrine cells, and Catestatin (CST: hCgA_352‐372), the most abundant CgA‐derived proteolytic peptide, affect the gut barrier...

article

ACE2 in the second act of COVID‐19 syndrome: Peptide dysregulation and possible correction with oestrogen

Limei Zhang, Mario A. Zetter, Enrique C. Guerra, Vito S. Hernández, more

Journal of Neuroendocrinology > 33 > 2 > n/a - n/a

Coronavirus disease 2019 (COVID‐19) has become the most critical pandemic of the 21st Century and the most severe since the 1918 influenza pandemic. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infects the host by binding to angiotensin‐converting enzyme 2 (ACE2). The role of ACE2 in the pathophysiology of coronavirus disease 2019 (COVID‐19) is a topic of debate, with clinical and...

article

Cover Image, Volume 1455, Issue 1

Sushil K. Mahata, Angelo Corti

Annals of the New York Academy of Sciences > 1455 > 1 > i - i

On the front cover: The cover image, submitted by Mahata and Corti, is from the review article “Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation,” https://doi.org/10.1111/nyas.14249.

article

Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation

Sushil K. Mahata, Angelo Corti

Annals of the New York Academy of Sciences > 1455 > 1 > 34 - 58

Chromogranin A (CgA)—the index member of the chromogranin/secretogranin secretory protein family—is ubiquitously distributed in endocrine, neuroendocrine, and immune cells. Elevated levels of CgA‐related polypeptides, consisting of full‐length molecules and fragments, are detected in the blood of patients suffering from neuroendocrine tumors, heart failure, renal failure, hypertension, rheumatoid...

article

Catestatin regulates vesicular quanta through modulation of cholinergic and peptidergic (PACAPergic) stimulation in PC12 cells

Bhavani Shankar Sahu, Sumana Mahata, Keya Bandyopadhyay, Manjula Mahata, more

Cell and Tissue Research > 2019 > 376 > 1 > 51-70

We have previously shown that the chromogranin A (CgA)-derived peptide catestatin (CST: hCgA_352–372) inhibits nicotine-induced secretion of catecholamines from the adrenal medulla and chromaffin cells. In the present study, we seek to determine whether CST regulates dense core (DC) vesicle (DCV) quanta (catecholamine and chromogranin/secretogranin proteins) during acute (0.5-h treatment) or chronic...

article

Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling

Charles McWherter, Yun-Jung Choi, Ramon L. Serrano, Sushil K. Mahata, more

Arthritis Research & Therapy > 2018 > 20 > 1 > 1-11

Background Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed decreased acute arthritis flares in arhalofenate-treated gout compared with allopurinol alone. Hence, we investigated the anti-inflammatory effects and mechanisms of arhalofenate and...

article

Chromogranin A regulates vesicle storage and mitochondrial dynamics to influence insulin secretion

Joshua Wollam, Sumana Mahata, Matthew Riopel, Angelina Hernandez-Carretero, more

Cell and Tissue Research > 2017 > 368 > 3 > 487-501

Chromogranin A (CgA) is a prohormone and a granulogenic factor that regulates secretory pathways in neuroendocrine tissues. In β-cells of the endocrine pancreas, CgA is a major cargo in insulin secretory vesicles. The impact of CgA deficiency on the formation and exocytosis of insulin vesicles is yet to be investigated. In addition, no literature exists on the impact of CgA on mitochondrial function...

article

Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis

Indrani Sinha-Hikim, Theodore C. Friedman, Mark Falz, Victor Chalfant, more

Cell and Tissue Research > 2017 > 368 > 1 > 159-170

Cigarette smoking is an important risk factor for diabetes, cardiovascular disease and non-alcoholic fatty liver disease. The health risk associated with smoking can be aggravated by obesity. Smoking might also trigger cardiomyocyte (CM) apoptosis. Given that CM apoptosis has been implicated as a potential mechanism in the development of cardiomyopathy and heart failure, we characterize the key signaling...

article

Cystathionine: A novel oncometabolite in human breast cancer

Suvajit Sen, Brain Kawahara, Sushil K. Mahata, Rebecca Tsai, more

Archives of Biochemistry and Biophysics > 2016 > 604 > C > 95-102

In this study, we have identified cystathionine (CTH), a sulfur containing metabolite, to be selectively enriched in human breast cancer (HBC) tissues (∼50–100 pmoles/mg protein) compared with undetectable levels in normal breast tissues. The accumulation of CTH, specifically in HBC, was attributed to the overexpression of cystathionine beta synthase (CBS), its synthesizing enzyme, and the undetectable...

article

Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system

Nilima Biswas, Adam X. Maihofer, Saiful Anam Mir, Fangwen Rao, more

BMC Medical Genetics > 2016 > 17 > 1 > 1-11

Background Plasma coagulation Factor XIIa (Hageman factor; encoded by F12) and kallikrein (KAL or Fletcher factor; encoded by KLKB1) are proteases of the kallikerin-kinin system involved in converting the inactive circulating prorenin to renin. Renin is a key enzyme in the formation of angiotensin II, which regulates blood pressure, fluid and electrolyte balance and is a biomarker for cardiovascular,...

article

Erratum to: Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo

Teresa Pasqua, Sumana Mahata, Gautam K. Bandyopadhyay, Angshuman Biswas, more

Cell and Tissue Research > 2016 > 363 > 3 > 823-823

The online version of the original article can be found at http://dx.doi.org/10.1007/s00441-015-2316-3 .

article

Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo

Teresa Pasqua, Sumana Mahata, Gautam K. Bandyopadhyay, Angshuman Biswas, more

Cell and Tissue Research > 2016 > 363 > 3 > 693-712

Chromogranin A (CgA) is a prohormone and granulogenic factor in neuroendocrine tissues with a regulated secretory pathway. The impact of CgA depletion on secretory granule formation has been previously demonstrated in cell culture. However, studies linking the structural effects of CgA deficiency with secretory performance and cell metabolism in the adrenomedullary chromaffin cells in vivo have not...

article

The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice

Linlin Zhong, Yun Ding, Gautam Bandyopadhyay, Jo Waaler, more

Diabetologia > 2016 > 59 > 3 > 582-591

Aims/hypothesis Tankyrase (TNKS) is a ubiquitously expressed molecular scaffold that is implicated in diverse processes. The catalytic activity of TNKS modifies substrate proteins through poly-ADP-ribosylation (PARsylation) and is responsive to cellular energetic state. Global deficiency of the TNKS protein in mice accelerates glucose utilisation and raises plasma adiponectin levels. The aim of this...

article

Chromogranin B: intra‐ and extra‐cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms

Kuixing Zhang, Nilima Biswas, Jiaur R. Gayen, Jose Pablo Miramontes‐Gonzalez, more

Journal of Neurochemistry > 129 > 1 > 48 - 59

Chromogranin B (CHGB) is the major matrix protein in human catecholamine storage vesicles. CHGB genetic variation alters catecholamine secretion and blood pressure. Here, effective Chgb protein under‐expression was achieved by siRNA in PC12 cells, resulting in ~ 48% fewer secretory granules on electron microscopy, diminished capacity for catecholamine uptake (by ~ 79%), and a ~ 73% decline in stores...

article

Development of a pharmacophore model for the catecholamine release-inhibitory peptide catestatin: Virtual screening and functional testing identify novel small molecule therapeutics of hypertension

Igor F. Tsigelny, Valentina L. Kouznetsova, Nilima Biswas, Sushil K. Mahata, more

Bioorganic & Medicinal Chemistry > 2013 > 21 > 18 > 5855-5869

The endogenous catecholamine release-inhibitory peptide catestatin (CST) regulates events leading to hypertension and cardiovascular disease. Earlier we studied the structure of CST by NMR, molecular modeling, and amino acid scanning mutagenesis. That structure has now been exploited for elucidation of interface pharmacophores that mediate binding of CST to its target, with consequent secretory inhibition...

article

Expression variations of chromogranin A and α1,2,4 GABAARs in discrete limbic and brainstem areas rescue cardiovascular alterations

Ennio Avolio, Rosa Maria Facciolo, Raffaella Alò, Maria Mele, more

Neuroscience Research > 2013 > 77 > 1-2 > 8-15

Recent interferences of hemodynamic functions via modified brain neuronal mechanisms have proven to be major causes of dementia and sleeping disorders. In this work, cerebral expression differences of the neuroactive vesicular chromogranin A (CgA) and distinct α GABA _A R subunits were detected in the facultative hibernating hamster. In particular, damaged neuronal fields of hypotensive torpor...

article

Chromogranin A and Derived Peptides in Health and Disease

Y. Peng Loh, Yong Cheng, Sushil K. Mahata, Angelo Corti, more

Journal of Molecular Neuroscience > 2012 > 48 > 2 > 347-356

Chromogranin A (CgA) is a member of the granins, a family of acidic proteins found in abundance in (neuro)endocrine cells (e.g., in chromaffin cells) and in some tumors. Like other granins, CgA has a granulogenic role in secretory granule biogenesis and is stored in these organelles. CgA is partially processed differentially in various cell types to yield biologically active peptides, such as vasostatin,...

article

Minocycline suppresses oxidative stress and attenuates fetal cardiac myocyte apoptosis triggered by in utero cocaine exposure

Indrani Sinha-Hikim, Ruoqing Shen, Ify Nzenwa, Robert Gelfand, more

Apoptosis > 2011 > 16 > 6 > 563-573

This study investigates the molecular mechanisms by which minocycline, a second generation tetracycline, prevents cardiac myocyte death induced by in utero cocaine exposure. Timed mated pregnant Sprague-Dawley (SD) rats received one of the following treatments twice daily from embryonic (E) day 15–21 (E15–E21): (i) intraperitoneal (IP) injections of saline (control); (ii) IP injections of cocaine...

article

Catecholamine biosynthesis and secretion: physiological and pharmacological effects of secretin

Manjula Mahata, Kuizing Zhang, Jiaur R. Gayen, Suvobroto Nandi, more

Cell and Tissue Research > 2011 > 345 > 1 > 87-102

Pituitary adenylyl cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) augment the biosynthesis of tyrosine hydroxylase (TH). We tested whether secretin belonging to the glucagon/PACAP/VIP superfamily would increase transcription of the tyrosine hydroxylase (Th) gene and modulate catecholamine secretion. Secretin activated transcription of the endogenous Th gene and...

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INFONA - science communication portal

Search results for: Sushil K. Mahata

Catestatin induces glycogenesis by stimulating the phosphoinositide 3‐kinase‐AKT pathway

Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides

ACE2 in the second act of COVID‐19 syndrome: Peptide dysregulation and possible correction with oestrogen

Cover Image, Volume 1455, Issue 1

Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation

Catestatin regulates vesicular quanta through modulation of cholinergic and peptidergic (PACAPergic) stimulation in PC12 cells

Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling

Chromogranin A regulates vesicle storage and mitochondrial dynamics to influence insulin secretion

Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis

Cystathionine: A novel oncometabolite in human breast cancer

Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system

Erratum to: Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo

Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo

The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice

Chromogranin B: intra‐ and extra‐cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms

Development of a pharmacophore model for the catecholamine release-inhibitory peptide catestatin: Virtual screening and functional testing identify novel small molecule therapeutics of hypertension

Expression variations of chromogranin A and α1,2,4 GABAARs in discrete limbic and brainstem areas rescue cardiovascular alterations

Chromogranin A and Derived Peptides in Health and Disease

Minocycline suppresses oxidative stress and attenuates fetal cardiac myocyte apoptosis triggered by in utero cocaine exposure

Catecholamine biosynthesis and secretion: physiological and pharmacological effects of secretin

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