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Am80 is a synthetic retinoid that has been used clinically for patients with acute promyelocytic leukemia and has been reported to affect the brain and its neurons. We investigated the influence of Am80 on anti-anxiety-like behavior, which is a characteristic of age-associated emotional disorder, in the P8 strain of senescence-accelerated mice (SAMP8). Am80 at a concentration of 2mg/kg/day was administered...
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