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We have investigated the effects of tCFA15, a non-peptidic compound, on the differentiation of neural stem cell-derived neurospheres, and have found that tCFA15 promotes their differentiation into neurons and reduces their differentiation into astrocytes, in a dose-dependent manner. This response is reminiscent of that resulting from the loss-of-function of Notch signaling after inactivation of the...
Neural stem cells cultured as neurospheres were used to assess the effects of P. notoginseng on the production of neurons and glia. The crude saponins (PNS) and ginsenoside-Rd promote the differentiation of neurospheres into astrocytes. Ginsenoside-Rd increases the production of astrocytes in a dose-dependent manner. On the other hand, both PNS and ginsenoside-Rd induce a weak but significant effect...
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