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Experiments were performed to see whether the thermogenic agent 2,4-dinitrophenol (DNP) can delay the onset of hypothermia in cold exposed rats. Warm (WA; T a 30 o C) or cold (CA; T a 5 o C) acclimatized adult rats injected (ip) with either saline or 5, 10 or 20 mg.0,3kg -1 DNP were exposed to warm (T a 30 o C) or cold (T a 10 ...
The proinflammatory cytokine, interleukin-1, is synthesized in neuronal and glial cells and is released in response to stress/injury. IL-1 exerts profound effects on the central nervous system, which include an inhibitory effect on synaptic activity in hippocampus, a brain area expressing a high density of IL-1 receptors. We report that IL-1β has an inhibitory effect on KCl-stimulated release of glutamate...
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