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Introduction: T cells from HIV-infected subjects are hyporesponsive to stimulation with various superantigens, mimicking physiological TCR-triggering. It is not clear, however, whether the defect is restricted to CD4 or CD8 T cells, whether it is due to intrinsic T cell dysfunction or to defective interaction with APC. The relation between reduced proliferation, increased apoptosis and altered cytokine...
Introduction: The production of regulatory cytokines during HIV infection and their potential immunomodulatory effects have been studied extensively. However, few studies were focused on whether the T cells from HIV-infected persons displayed an altered sensitivity to these cytokines. Therefore, we wanted to compare the responsiveness of CD4+ and CD8+ T cells from HIV-infected patients and HIV-negative...
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