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Background: Ventricular pre-excitation by VDD pacing with a short AV delay is a potential therapy for patients with dilated heart failure (DCM). However, the optimal pacing site may not be the right ventricular apex, as is mostly widely employed.Methods: Cardiac catheterization by pressure-volume analysis was performed in 14 pts with DCM (NYHA-III-IV, mean EF 19 +/- 2%). Baseline QRS and PR intervals...
Nitric oxide (NO) has been shown to inhibit the β-adrenergic inotropic response in humans with left ventricular dysfunction. Angiotensin converting enzyme (ACE) inhibitors increase bradykinin, an agonist of NO synthase, by inhibiting kininase II. We hypothesized that ACE inhibitors would produce a NO modulated negative inotropic effect independent of angiotensin receptor-1 (AT-1). Eight patients...