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The structure of r(GGAGGAGGAGGA) (R12) changes from a single‐stranded form to a compact quadruplex one in response to K+. In a hammerhead ribozyme, two portions of the catalytic core are linked with the stem and are located in close proximity in order to exert activity. In this study, the stem was replaced by R12 (or R11, which lacks the terminal A residue) with or without linker residues. One of...
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