Search results for: Hillard M. Lazarus

Items from 1 to 20 out of 188 results

article

Cell‐type specific molecular expression levels by restricted‐dimensional cytometry

David Kaplan, Hillard M. Lazarus, Eric Christian

European Journal of Clinical Investigation > 54 > 8 > n/a - n/a

Background Cytometric analysis has been commonly used to delineate distinct cell subpopulations among peripheral blood mononuclear cells by the differential expression of surface receptors. This capability has reached its apogee with high‐dimensional approaches such as mass cytometry and spectral cytometry that include simultaneous assessment of 20–50 analytes. Unfortunately, this approach also engenders...

article

GM‐CSF, G‐CSF or no cytokine therapy with anti‐GD2 immunotherapy for high‐risk neuroblastoma

Jaume Mora, Shakeel Modak, Joyce Kinsey, Carolyn E. Ragsdale, more

International Journal of Cancer > 154 > 8 > 1340 - 1364

Colony‐stimulating factors have been shown to improve anti‐disialoganglioside 2 (anti‐GD2) monoclonal antibody response in high‐risk neuroblastoma by enhancing antibody‐dependent cell‐mediated cytotoxicity (ADCC). A substantial amount of research has focused on recombinant human granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) as an adjuvant to anti‐GD2 monoclonal antibodies. There may be...

article

Obesity in adult acute myeloid leukemia is not associated with inferior response or survival even when dose capping anthracyclines: An ECOG‐ACRIN analysis

James M. Foran, Zhuoxin Sun, Catherine Lai, Hugo F. Fernandez, more

Cancer > 129 > 16 > 2479 - 2490

Background Obesity (body mass index [BMI] ≥30 kg/m²) is an important epidemiological risk factor for developing acute myeloid leukemia (AML). Therefore, the authors studied the association of obesity with clinical and genetic phenotype and its impact on outcome in adults with AML. Methods The authors analyzed BMI in 1088 adults who were receiving intensive remission induction and consolidation...

article

Impact of bortezomib‐based versus lenalidomide maintenance therapy on outcomes of patients with high‐risk multiple myeloma

Naresh Bumma, Binod Dhakal, Raphael Fraser, Noel Estrada‐Merly, more

Cancer > 129 > 14 > 2179 - 2191

Background Lenalidomide maintenance after autologous stem cell transplant (ASCT) in multiple myeloma (MM) results in superior progression‐free survival and overall survival. However, patients with high‐risk multiple myeloma (HRMM) do not derive the same survival benefit from lenalidomide maintenance compared with standard‐risk patients. The authors sought to determine the outcomes of bortezomib‐based...

article

Does recipient body mass index inform donor selection for allogeneic haematopoietic cell transplantation?

Mouhamed Yazan Abou‐Ismail, Raphael Fraser, Mariam Allbee‐Johnson, Leland Metheny, more

British Journal of Haematology > 197 > 3 > 326 - 338

It is not known whether obesity has a differential effect on allogeneic haematopoietic cell transplantation outcomes with alternative donor types. We report the results of a retrospective registry study examining the effect of obesity [body mass index (BMI) > 30] on outcomes with alternative donors (haploidentical related donor with two or more mismatches and receiving post‐transplant cyclophosphamide...

article

Prognostic effect of gender on outcome of treatment for adults with acute myeloid leukaemia

Peter H. Wiernik, Zhuoxin Sun, Larry D. Cripe, Jacob M. Rowe, more

British Journal of Haematology > 194 > 2 > 309 - 318

There are conflicting reports in the literature suggesting that one gender or the other has a better survival with acute myeloid leukaemia (AML). The present study was done in an attempt to resolve the issue. The effect of gender was examined on 3546 newly diagnosed patients with AML, including 548 patients with acute promyelocytic leukaemia (APL) enrolled in 10 multi‐institutional treatment studies...

article

Incidence and impact of community respiratory viral infections in post‐transplant cyclophosphamide‐based graft‐versus‐host disease prophylaxis and haploidentical stem cell transplantation

Carolyn M. Mulroney, Muhammad Bilal Abid, Asad Bashey, Roy F. Chemaly, more

British Journal of Haematology > 194 > 1 > 145 - 157

Community respiratory viral infections (CRVIs) are associated with pulmonary function impairment, alloimmune lung syndromes and inferior survival in human leucocyte antigen (HLA)‐matched allogeneic haematopoietic stem cell transplant (HCT) recipients. Although the incidence of viral infections in HLA‐haploidentical HCT recipients who receive post‐transplant cyclophosphamide (PTCy)‐based graft‐versus...

article

African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States

Talha Badar, Parameswaran Hari, Omar Dávila, Raphael Fraser, more

Cancer > 127 > 1 > 82 - 92

Background Multiple myeloma (MM) with the translocation t(11;14) may have inferior outcomes in comparison with other standard‐risk MM, and it has been suggested to portend a worse prognosis in African Americans in comparison with Whites. This study used the Center for International Blood and Marrow Transplant Research (CIBMTR) database to examine the impact of t(11;14) on the clinical outcomes of...

article

Age no bar: A CIBMTR analysis of elderly patients undergoing autologous hematopoietic cell transplantation for multiple myeloma

Pashna N. Munshi, David Vesole, Artur Jurczyszyn, Jan Maciej Zaucha, more

Cancer > 126 > 23 > 5077 - 5087

Background Upfront autologous hematopoietic stem cell transplantation (AHCT) remains an important therapy in the management of patients with multiple myeloma (MM), a disease of older adults. Methods The authors investigated the outcomes of AHCT in patients with MM who were aged ≥70 years. The Center for International Blood and Marrow Transplant Research (CIBMTR) database registered 15,999 patients...

article

At three years, patients with acute lymphoblastic leukaemia are still at risk for relapse. Results of the international MRC UKALLXII/ECOG E2993 trial

Chezi Ganzel, Xin V. Wang, Jacob M. Rowe, Susan M. Richards, more

British Journal of Haematology > 191 > 1 > 37 - 43

Late relapse [>3 years from complete remission (CR)] in acute lymphoblastic leukaemia (ALL), is unusual. Data from the MRC UKALLXII/ECOG E2993 trial are presented to evaluate the incidence and characteristics of late relapse in adult ALL. Of 1,909 patients, 1,752 (92%) achieved CR and among these 757 (43·2%) relapsed; 691 (91·3%) within three years and 66 (8·7%) beyond. Among these 66 patients,...

article

Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation

Mitchell S. Cairo, Kenneth R. Cooke, Hillard M. Lazarus, Nelson Chao

British Journal of Haematology > 190 > 6 > 822 - 836

Sinusoidal obstruction syndrome (SOS), previously known as hepatic veno‐occlusive disease (VOD), remains a multi‐organ system complication following haematopoietic cell transplantation (HCT). When SOS/VOD is accompanied by multi‐organ dysfunction, overall mortality rates remain >80%. However, the definitions related to the diagnosis and grading of SOS/VOD after HCT are almost 25 years old and require...

article

Incorporation of extracorporeal photopheresis into a reduced intensity conditioning regimen in myelodysplastic syndrome and aggressive lymphoma: results from ECOG 1402 and 1902

Francine M. Foss, Xin Victoria Wang, Selina M. Luger, Opeyemi Jegede, more

Transfusion > 60 > 8 > 1867 - 1872

Background Extracorporeal photopheresis (ECP) is an immunomodulatory cellular therapy which has been shown to induce a tolerogenic state in patients with acute and chronic graft‐vs‐host disease. ECOG‐ACRIN explored the activity of ECP as a part of a reduced intensity conditioning regimen in two multicenter trials in patients with MDS (E1902) and lymphomas (E1402). While both studies closed before...

article

Aggressive lymphoma subtype is a risk factor for venous thrombosis. Development of lymphoma ‐ specific venous thrombosis prediction models

Gouri Dharmavaram, Shufen Cao, Suchitra Sundaram, Sabarish Ayyappan, more

American Journal of Hematology > 95 > 8 > 918 - 926

Venous thromboembolic events (VTE) are a frequent complication of lymphoma. We conducted a retrospective analysis to compare VTE risk in diffuse large B‐cell lymphoma (DLBCL) and follicular lymphoma (FL). Subjects were randomly assigned to training and validation sets to identify risk factors of VTE and evaluate risk model performance, including the Khorana score. A group of 790 patients were diagnosed...

article

Incidence, Risk Factors for and Outcomes of Transplant‐Associated Thrombotic Microangiopathy

Narendranath Epperla, Ang Li, Brent Logan, Caitrin Fretham, more

British Journal of Haematology > 189 > 6 > 1171 - 1181

Transplant‐associated thrombotic microangiopathy (TA‐TMA) is a complication of allogeneic transplantation (allo‐HCT). The incidence and risk factors associated with TA‐TMA are not well known. A retrospective analysis from the Center for International Blood and Marrow Transplant Research (CIBMTR) was conducted including patients receiving allo‐HCT between 2008 and 2016, with the primary objective of...

article

Bacterial contamination and septic transfusion reaction rates associated with platelet components before and after introduction of primary culture: experience at a US Academic Medical Center 1991 through 2017

Sirisha Kundrapu, Swati Srivastava, Caryn E. Good, Hillard M. Lazarus, more

Transfusion > 60 > 5 > 974 - 985

BACKGROUND The high incidence of septic transfusion reactions (STRs) led to testing being mandated by AABB from 2004. This was implemented by primary culture of single‐donor apheresis platelets (APs) from 2004 and prestorage pooled platelets (PSPPs) from 2007. STUDY DESIGN/METHODS Platelet (PLT) aliquots were cultured at issue and transfusion reactions evaluated at our hospital. Bacterial contamination...

article

Outcomes of rituximab‐BEAM versus BEAM conditioning regimen in patients with diffuse large B cell lymphoma undergoing autologous transplantation

Deepa Jagadeesh, Navneet S. Majhail, Yizeng He, Kwang W. Ahn, more

Cancer > 126 > 10 > 2279 - 2287

Background Although rituximab‐based high‐dose therapy is frequently used in diffuse large B cell lymphoma (DLBCL) patients undergoing autologous hematopoietic cell transplantation (auto‐HCT), data supporting the benefits are not available. Herein, we report the impact of rituximab‐based conditioning on auto‐HCT outcomes in patients who have DLBCL. Methods Using the Center for International Blood...

article

Survival outcomes of allogeneic hematopoietic cell transplants with EBV‐positive or EBV‐negative post‐transplant lymphoproliferative disorder, A CIBMTR study

Seema Naik, Marcie Riches, Parameswaran Hari, Soyoung Kim, more

Transplant Infectious Disease > 21 > 5 > n/a - n/a

Background Post‐transplant lymphoproliferative disorders (PTLD) are associated with significant morbidity and mortality following allogeneic hematopoietic cell transplant (alloHCT). Although most PTLD is EBV‐positive (EBV^pos), EBV‐negative (EBV^neg) PTLD is reported, yet its incidence and clinical impact remain largely undefined. Furthermore, factors at the time of transplant impacting survival following...

article

A randomized trial of three novel regimens for recurrent acute myeloid leukemia demonstrates the continuing challenge of treating this difficult disease

Mark R. Litzow, Xin V. Wang, Martin P. Carroll, Judith E. Karp, more

American Journal of Hematology > 94 > 1 > 111 - 117

To improve the outcome of relapsed/refractory acute myeloid leukemia (AML), a randomized phase II trial of three novel regimens was conducted. Ninety patients were enrolled and were in first relapse or were refractory to induction/re‐induction chemotherapy. They were randomized to the following regimens: carboplatin‐topotecan (CT), each by continuous infusion for 5 days; alvocidib (formerly flavopiridol),...

article

Very poor long‐term survival in past and more recent studies for relapsed AML patients: The ECOG‐ACRIN experience

Chezi Ganzel, Zhuoxin Sun, Larry D. Cripe, Hugo F. Fernandez, more

American Journal of Hematology > 93 > 8 > 1074 - 1081

This study examines the long‐term OS of relapsed AML patients who were enrolled to 9 successive ECOG‐ACRIN trials for newly diagnosed AML, during 1984‐2008. The objectives were to examine whether there is a trend of improvement in the survival of relapsed AML patients in the more recent studies and to search for prognostic factors that are associated with long‐term OS after relapse. A total of 3012...

article

Anti-cancer vaccine therapy for hematologic malignancies: An evolving era

Myrna R. Nahas, Jacalyn Rosenblatt, Hillard M. Lazarus, David Avigan

Blood Reviews > 2018 > 32 > 4 > 312-325

The potential promise of therapeutic vaccination as effective therapy for hematologic malignancies is supported by the observation that allogeneic hematopoietic cell transplantation is curative for a subset of patients due to the graft-versus-tumor effect mediated by alloreactive lymphocytes. Tumor vaccines are being explored as a therapeutic strategy to re-educate host immunity to recognize and target...

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Search results for: Hillard M. Lazarus

Cell‐type specific molecular expression levels by restricted‐dimensional cytometry

GM‐CSF, G‐CSF or no cytokine therapy with anti‐GD2 immunotherapy for high‐risk neuroblastoma

Obesity in adult acute myeloid leukemia is not associated with inferior response or survival even when dose capping anthracyclines: An ECOG‐ACRIN analysis

Impact of bortezomib‐based versus lenalidomide maintenance therapy on outcomes of patients with high‐risk multiple myeloma

Does recipient body mass index inform donor selection for allogeneic haematopoietic cell transplantation?

Prognostic effect of gender on outcome of treatment for adults with acute myeloid leukaemia

Incidence and impact of community respiratory viral infections in post‐transplant cyclophosphamide‐based graft‐versus‐host disease prophylaxis and haploidentical stem cell transplantation

African Americans with translocation t(11;14) have superior survival after autologous hematopoietic cell transplantation for multiple myeloma in comparison with Whites in the United States

Age no bar: A CIBMTR analysis of elderly patients undergoing autologous hematopoietic cell transplantation for multiple myeloma

At three years, patients with acute lymphoblastic leukaemia are still at risk for relapse. Results of the international MRC UKALLXII/ECOG E2993 trial

Modified diagnostic criteria, grading classification and newly elucidated pathophysiology of hepatic SOS/VOD after haematopoietic cell transplantation

Incorporation of extracorporeal photopheresis into a reduced intensity conditioning regimen in myelodysplastic syndrome and aggressive lymphoma: results from ECOG 1402 and 1902

Aggressive lymphoma subtype is a risk factor for venous thrombosis. Development of lymphoma ‐ specific venous thrombosis prediction models

Incidence, Risk Factors for and Outcomes of Transplant‐Associated Thrombotic Microangiopathy

Bacterial contamination and septic transfusion reaction rates associated with platelet components before and after introduction of primary culture: experience at a US Academic Medical Center 1991 through 2017

Outcomes of rituximab‐BEAM versus BEAM conditioning regimen in patients with diffuse large B cell lymphoma undergoing autologous transplantation

Survival outcomes of allogeneic hematopoietic cell transplants with EBV‐positive or EBV‐negative post‐transplant lymphoproliferative disorder, A CIBMTR study

A randomized trial of three novel regimens for recurrent acute myeloid leukemia demonstrates the continuing challenge of treating this difficult disease

Very poor long‐term survival in past and more recent studies for relapsed AML patients: The ECOG‐ACRIN experience

Anti-cancer vaccine therapy for hematologic malignancies: An evolving era

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