The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
After intracerebral injection, some toxic secreted phospholipases A2 (sPLA2) can induce epileptic seizures. Because of their high affinity for some neuronal receptors, these toxic sPLA2s could be very valuable pharmacological tools to investigate the role of endogenous sPLA2 in other models of epileptic seizures. The scarce data found in the literature strongly suggest a high variability of the...
Paradoxin (PDX), purified from the Australian Elapid snake Oxyuranus microlepidotus venom is a little-studied toxin that belongs to the β-neurotoxin family, a group of potent snake neurotoxins having PLA 2 catalytic properties. PDX was first described 15 years ago as a taipoxin-like toxin (taipoxin is a three chain β-neurotoxin isolated from the Taipan snake, O. s. scutellatus). Since 1979,...
Paradoxin, purified from the venom of the Australian elapid snake Oxyuranus microlepidotus, is a little-studied toxin that belongs to the β-neurotoxin family, a group of potent snake neurotoxins having PLA 2 (phospholipase A 2 ) catalytic properties. Paradoxin (PDX) was first described 15 years ago as a taipoxin-like toxin (taipoxin is a three-chain β-neurotoxin isolated from the...
α-Dendrotoxin (α-DTX) is a 59 amino acid polypeptide isolated from the eastern green mamba (Dendroaspis angusticeps) snake venom which blocks certain types of fast-activating, voltage-dependent potassium channels. Intracerebral injection of α-DTX induces severe seizures and neuropathological changes in several areas of the brain, as shown by benzodiazepine ω 3 binding-site measurements (Lallement...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.