Search results for: Xinjian Liu

Items from 1 to 20 out of 47 results

article

USP12 promotes nonsmall cell lung cancer progression through deubiquitinating and stabilizing RRM2

Congcong Chen, Ning Xue, Kangshou Liu, Qiang He, more

Molecular Carcinogenesis > 62 > 10 > 1518 - 1530

RRM2 is the catalytic subunit of ribonucleotide reductase (RNR), which catalyzes de novo synthesis of deoxyribonucleotide triphosphates (dNTPs) and plays critical roles in cancer cell proliferation. RRM2 protein level is controlled by ubiquitination mediated protein degradation system; however, its deubiquitinase has not been identified yet. Here we showed that ubiquitin‐specific peptidase 12 (USP12)...

article

Praziquantel ameliorates CCl₄‐induced liver fibrosis in mice by inhibiting TGF‐β/Smad signalling via up‐regulating Smad7 in hepatic stellate cells

Jinfeng Liu, Delong Kong, Jingfan Qiu, Yanci Xie, more

British Journal of Pharmacology > 176 > 24 > 4666 - 4680

Background and Purpose Praziquantel is a schistosomicide, which has been used for more than 30 years due to its efficiency, safety, and mild side effects. Previous studies showed that prolonged treatment with praziquantel suppressed the development of liver fibrosis in mice with schistosomiasis. In this study, we investigated the potential mechanisms underlying the antifibrotic effects of praziquantel...

article

Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway

Yiwei Wang, Minghui Zhao, Sijia He, Yuntao Luo, more

Journal of Experimental & Clinical Cancer Research > 2019 > 38 > 1 > 1-16

Background Tumor cell repopulation after radiotherapy is a major cause for the tumor radioresistance and recurrence. This study aims to investigate the underlying mechanism of tumor repopulation after radiotherapy, with focus on whether and how necroptosis takes part in this process. Methods Necroptosis after irradiation were examined in vitro and in vivo. And the growth-promoting effect of necroptotic...

article

Prediction of thrombosis risk in patients with paroxysmal nocturnal hemoglobinuria

Yuzhou Huang, Xinjian Liu, Fangfei Chen, Wenzhe Zhou, more

Annals of Hematology > 2019 > 98 > 10 > 2283-2291

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic disease with thrombosis as a major complication. The mechanism of thrombosis and related risk factors in PNH patients are still not well characterized. We retrospectively enrolled 99 patients with newly diagnosed PNH at our institute from 2011 to 2016. According to binary logistic regression model analysis, we first identified four...

article

Non-apoptotic Roles of Caspases in Stem Cell Biology, Carcinogenesis, and Radiotherapy

Rayan Kaakati, Ruya Zhao, Xuhui Bao, Andrew K. Lee, more

Current Stem Cell Reports > 2019 > 5 > 1 > 31-37

Purpose of Review To summarize recent findings on novel roles of caspases in stem cell biology, tumor repopulation, and tissue regeneration. Contrary to the long-held notion that apoptotic caspases are exclusively executioners of programmed cell death, an abundance of evidence is emerging that activation of caspases does not inevitably lead to cell death. Recent Findings It is now known that sublethal...

article

Caspase‐3 regulates the migration, invasion and metastasis of colon cancer cells

Min Zhou, Xinjian Liu, Zonghai Li, Qian Huang, more

International Journal of Cancer > 143 > 4 > 921 - 930

Caspase‐3 (CASP3) is a major mediator of apoptosis activated during cellular exposure to cytotoxic drugs, radiotherapy or immunotherapy. It is often used as a marker for efficacy of cancer therapy. However, recent reports indicate that caspase‐3 has also non‐apoptotic roles such as promotion of tumor relapse and tumor angiogenesis. Therefore, the roles of caspase‐3 in tumor progression remain to be...

article

Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond

Ruya Zhao, Rayan Kaakati, Andrew K. Lee, Xinjian Liu, more

Cancer and Metastasis Reviews > 2018 > 37 > 2-3 > 227-236

Apoptotic caspases have long been studied for their roles in programmed cell death and tumor suppression. With recent discoveries, however, it is becoming apparent these cell death executioners are involved in additional biological pathways beyond killing cells. In some cases, apoptotic cells secrete growth signals to stimulate proliferation of neighboring cells. This pathway functions to regenerate...

article

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

Guangfu Li, Dai Liu, Eric T. Kimchi, Jussuf T. Kaifi, more

Gastroenterology > 2018 > 154 > 4 > 1024-1036.e9

Ceramide, a sphingolipid metabolite, affects T-cell signaling, induces apoptosis of cancer cells, and slows tumor growth in mice. However, it has not been used as a chemotherapeutic agent because of its cell impermeability and precipitation in aqueous solution. We developed a nanoliposome-loaded C6-ceremide (LipC6) to overcome this limitation and investigated its effects in mice with liver tumors...

article

Efficacy and safety of G-CSF, low-dose cytarabine and aclarubicin in combination with l-asparaginase, prednisone in the treatment of refractory or relapsed acute lymphoblastic leukemia

Keshu Zhou, Yongping Song, Yanli Zhang, Xudong Wei, more

Leukemia Research > 2017 > 62 > C > 29-33

Acute lymphoblastic leukemia (ALL) patients who fail to acquire complete remission (CR) or who relapse after initial response have poor prognosis. At present there is no consensus as to the standard salvage therapy for these patients. In this study, we retrospectively evaluate safety and efficacy of a salvage regimen (CAGLP) consisting of G-CSF, low-dose cytarabine, aclarubicin, l-asparaginase and...

article

Corrigendum to “Thermal management of cylindrical power battery module for extending the life of new energy electric vehicles” [Appl. Thermal Eng. 85 (2015) 33–43]

Jiateng Zhao, Zhonghao Rao, Yutao Huo, Xinjian Liu, more

Applied Thermal Engineering > 2017 > 122 > C > 833

article

Association of insulin-like growth factor-1 receptor polymorphism and insulin-like growth factor-1 plasma level with chronic immune thrombocytopenia in Chinese population

Liu Liu, Lulu Su, Jingyi Yang, Huiyuan Li, more

Meta Gene > 2017 > 11 > C > 1-4

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated low platelet count and suppression of megakaryocyte development. Abnormalities of cell-mediated immunity have drawn more and more attention in the pathologic process of ITP. Insulin-like growth factor-1(IGF-1) plays an important role in the regulation of immune response and inflammation, which takes place in innate and...

article

Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism

Xiao Feng, Yang Yu, Sijia He, Jin Cheng, more

Cancer Letters > 2017 > 385 > C > 12-20

Vascular recovery or re-angiogenesis after radiotherapy plays a significant role in tumor recurrence, whereas molecular mechanisms of this process remain elusive. In this work, we found that dying glioma cells promoted post-irradiation angiogenesis through a caspase 3 dependent mechanism. Evidence in vitro and in vivo indicated that caspase 3 inhibition undermined proangiogenic effects of dying glioma...

article

eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation

Yang Yu, Ling Tian, Xiao Feng, Jin Cheng, more

Cancer Letters > 2016 > 375 > 1 > 31-38

Pancreatic cancer is a devastating disease characterized by treatment resistance and high recurrence rate. Repopulation of surviving tumor cells undergoing radiotherapy is one of the most common reasons for recurrence. Our previous studies have discovered a novel mechanism for repopulation after irradiation that activation of caspase-3 in irradiated tumor cells activates PKCδ/p38 axis to transmit...

article

Thermal management of cylindrical power battery module for extending the life of new energy electric vehicles

Jiateng Zhao, Zhonghao Rao, Yutao Huo, Xinjian Liu, more

Applied Thermal Engineering > 2015 > 85 > Complete > 33-43

Thermal management especially cooling plays an important role in power battery modules for electric vehicles. In order to comprehensively understand the heat transfer characteristics of air cooling system, the air cooling numerical simulation battery models for cylindrical lithium-ion power battery pack were established in this paper, and a detailed parametric investigation was undertaken to study...

article

Caspase-3 Promotes Genetic Instability and Carcinogenesis

Xinjian Liu, Yujun He, Fang Li, Qian Huang, more

Molecular Cell > 2015 > 58 > 2 > 284-296

Apoptosis is typically considered an anti-oncogenic process since caspase activation can promote the elimination of genetically unstable or damaged cells. We report that a central effector of apoptosis, caspase-3, facilitates rather than suppresses chemical- and radiation-induced genetic instability and carcinogenesis. We found that a significant fraction of mammalian cells treated with ionizing radiation...

article

Increased monomeric CRP levels in acute myocardial infarction: A possible new and specific biomarker for diagnosis and severity assessment of disease

Junhong Wang, Bo Tang, Xinjian Liu, Xin Wu, more

Atherosclerosis > 2015 > 239 > 2 > 343-349

Monomeric CRP (mCRP) plays an important role in the process of atherosclerotic plaque rupture. Recently, it has been reported that mCRP was associated with acute myocardial infarction (AMI).The aim of this study was to examine whether mCRP is increased in AMI patients and to investigate the possibility of using circulating mCRP as a biomarker for AMI diagnosis and severity assessment of disease.A...

article

Investigation of power battery thermal management by using mini-channel cold plate

Yutao Huo, Zhonghao Rao, Xinjian Liu, Jiateng Zhao

Energy Conversion and Management > 2015 > 89 > Complete > 387-395

In order to guarantee the safety and extend the cycle life of Li-ion power batteries within electric vehicles, a mini-channel cold plate-based battery thermal management system is designed to cool a rectangular Li-ion battery. A three-dimensional thermal model of the cooling system was established and the effects of number of channels, flow direction, inlet mass flow rate and ambient temperature on...

article

A colorimetric method for the detection of folate receptor based on terminal protection-assisted cascade signal amplification

Jing Zhao, Suisui Hu, Xixian Chen, Bin Zhang, more

Sensors & Actuators: B. Chemical > 2014 > 202 > Complete > 1243-1247

In this paper, we have proposed a colorimetric method for the sensitive detection of folate receptor (FR) based on terminal protection-assisted cascade signal amplification. In the presence of target protein, the binding of FR and folate that is covalently conjugated at 3′ terminal of probe DNA can induce significant steric hindrance to prevent exonuclease I-catalyzed degradation of probe DNA. So,...

article

Experimental study of an OHP-cooled thermal management system for electric vehicle power battery

Zhonghao Rao, Yutao Huo, Xinjian Liu

Experimental Thermal and Fluid Science > 2014 > 57 > Complete > 20-26

Excessive high and low temperature can significantly reduce the performance of power battery. To extend the cycle life of battery and then improve the performance of electric vehicles, an oscillating heat pipe (OHP)-cooled battery thermal management (BTM) system was designed and experimentally studied in this paper. The results showed that the higher temperature section of battery should be near the...

article

Ultrasensitive detection of lead ion based on target induced assembly of DNAzyme modified gold nanoparticle and graphene oxide

Chao Li, Luming Wei, Xinjian Liu, Lin Lei, more

Analytica Chimica Acta > 2014 > 831 > Complete > 60-64

In this paper, we report a novel colorimetric strategy for the detection of small molecules by using Pb ²⁺ ion as an example. In this strategy, DNAzyme duplex modified gold nanoparticles (GNPs) are designed to be unable to interact with graphene oxide (GO). However, in the presence of Pb ²⁺ , the substrate strand of the DNAzyme is cleaved at its cleavage site, resulting in the disassembly...

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INFONA - science communication portal

Search results for: Xinjian Liu

USP12 promotes nonsmall cell lung cancer progression through deubiquitinating and stabilizing RRM2

Praziquantel ameliorates CCl₄‐induced liver fibrosis in mice by inhibiting TGF‐β/Smad signalling via up‐regulating Smad7 in hepatic stellate cells

Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway

Prediction of thrombosis risk in patients with paroxysmal nocturnal hemoglobinuria

Non-apoptotic Roles of Caspases in Stem Cell Biology, Carcinogenesis, and Radiotherapy

Caspase‐3 regulates the migration, invasion and metastasis of colon cancer cells

Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

Efficacy and safety of G-CSF, low-dose cytarabine and aclarubicin in combination with l-asparaginase, prednisone in the treatment of refractory or relapsed acute lymphoblastic leukemia

Corrigendum to “Thermal management of cylindrical power battery module for extending the life of new energy electric vehicles” [Appl. Thermal Eng. 85 (2015) 33–43]

Association of insulin-like growth factor-1 receptor polymorphism and insulin-like growth factor-1 plasma level with chronic immune thrombocytopenia in Chinese population

Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism

eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation

Thermal management of cylindrical power battery module for extending the life of new energy electric vehicles

Caspase-3 Promotes Genetic Instability and Carcinogenesis

Increased monomeric CRP levels in acute myocardial infarction: A possible new and specific biomarker for diagnosis and severity assessment of disease

Investigation of power battery thermal management by using mini-channel cold plate

A colorimetric method for the detection of folate receptor based on terminal protection-assisted cascade signal amplification

Experimental study of an OHP-cooled thermal management system for electric vehicle power battery

Ultrasensitive detection of lead ion based on target induced assembly of DNAzyme modified gold nanoparticle and graphene oxide

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