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In an attempt to increase the affinity of our antipsychotic lead compound LASSBio-579 (1-((1-(4-chlorophenyl)-1H-pyrazol-4-yl)methyl)-4-phenylpiperazine; (2)) for the 5-HT 2A receptor, we synthesized five new N-phenylpiperazine derivatives using a linear synthetic route and the homologation strategy. The binding profile of these compounds was evaluated for a series of dopaminergic, serotonergic...
Renal changes determined by Lys49 myotoxin I (BmTx I), isolated from Bothrops moojeni are well known. The scope of the present study was to investigate the possible mechanisms involved in the production of these effects by using indomethacin (10μg/mL), a non-selective inhibitor of cyclooxygenase, and tezosentan (10μg/mL), an endothelin antagonist. By means of the method of mesenteric vascular bed,...
Web services against SNMP comparisons have been carried out by the network management community in order to understand the impact on adopting Web services as a management tool. In these comparisons, however, notification messages have been neglected to a secondary plane in such a way that the current conclusions about the performance of Web services may not apply for networks extensively managed via...
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