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Corticotropin-releasing factor (CRF) induces the dilatation of cerebral blood vessels and increases cerebral blood flow (CBF). CRF receptor antagonists reduce ischaemic damage in the rat. In the present study, the expression of CRF around cerebral vessels has been investigated in the rat. No CRF immunoreactivity was identified around pial or intracerebral vessels in the absence of cerebral ischaemia...
The serotonin 1A receptor (5-HT 1A ) has been identified both as an inhibitory somatodendritic receptor in raphe serotonergic cells and a postsynaptic receptor in selective serotonergic terminal fields. Its abundance in the limbic system, as well as evidence from animal and clinical studies, strongly suggest that the 5-HT 1A receptor plays an important role in the pathophysiology...
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