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Trauma-focused cognitive behavioral therapy (TF-CBT) is an evidence-based psychological treatment that can effectively ameliorate symptoms of depression and anxiety that are common responses to trauma exposure. However, access to high-quality mental health services can be problematic, especially for traditionally underserved populations such as rural/remote residents, racial/ethnic minorities, and...
Among Shigella serotypes Shigella dysenteriae type 1 produces the most severe disease, including cases of hemolytic-uremic syndrome and pandemic outbreaks. WRSd1 is a live S. dysenteriae 1 strain attenuated by deletion of the virG(icsA) gene, which encodes a protein that mediates intercellular spread, and stxA and stxB, which encode the Shiga toxin. In this Phase I trial five groups of eight subjects...
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