Search results for: Serge Bonnefoy

Items from 1 to 7 out of 7 results

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Redistribution of FLAgellar Member 8 during the trypanosome life cycle: Consequences for cell fate prediction

Estefanía Calvo‐Álvarez, Serge Bonnefoy, Audrey Salles, Fiona E. Benson, more

Cellular Microbiology > 23 > 9 > n/a - n/a

The single flagellum of African trypanosomes is essential in multiple aspects of the parasites' development. The FLAgellar Member 8 protein (FLAM8), localised to the tip of the flagellum in cultured insect forms of Trypanosoma brucei, was identified as a marker of the locking event that controls flagellum length. Here, we investigated whether FLAM8 could also reflect the flagellum maturation state...

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Immunoglobulin response to Plasmodium falciparum RESA proteins in uncomplicated and severe malaria

Cyril Badaut, Léa Guyonnet, Jacqueline Milet, Emmanuelle Renard, more

Malaria Journal > 2015 > 14 > 1 > 1-13

Background The three members of the ring-infected erythrocyte surface antigen (RESA) proteins family share high sequence homologies, which impair the detection and assignment to one or another protein of some pathogenic processes inherent to Plasmodium falciparum malaria. The present study was intended to determine if the antibody and inflammatory responses of children living in a malaria-endemic...

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Deconstructing Export of Malaria Proteins

Serge Bonnefoy, Robert Ménard

Cell > 2008 > 134 > 1 > 20-22

The virulence of the malaria parasite Plasmodium falciparum is mediated by parasite proteins exported to the surface of infected erythrocytes. In this issue, Maier et al. (2008) report a screen of malaria parasite genes predicted to be involved in parasite protein export and trafficking within the host erythrocyte and discover that many more than expected are essential for parasite survival in vitro.

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A 24 bp cis-acting element essential for the transcriptional activity of Plasmodium falciparum CDP-diacylglycerol synthase gene promoter

Mike Osta, Leila Gannoun-Zaki, Serge Bonnefoy, Christian Roy, more

Molecular & Biochemical Parasitology > 2002 > 121 > 1 > 87 - 98

CDP-diacylglycerol synthase (CDS) is a key rate-limiting enzyme in the phospholipid metabolism of Plasmodium falciparum, converting phosphatidic acid to CDP-diacylglycerol. The CDS gene is predominantly expressed in the mature intraerythrocytic stages. Consequently, we physically and functionally characterized the CDS gene promoter. The mRNA transcription initiation site was mapped 121 bp upstream...

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Characterization of Plasmodium falciparum CDP-diacylglycerol synthase, a proteolytically cleaved enzyme

Dominique Martin, Leila Gannoun-Zaki, Serge Bonnefoy, Patrick Eldin, more

Molecular & Biochemical Parasitology > 2000 > 110 > 1 > 93 - 105

Cytidine diphosphate-diacylglycerol (CDP-DAG), an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids, is synthesized by CDP-DAG synthase (CDS). The gene encoding CDS was isolated from the human malaria parasite Plasmodium falciparum, based on sequence conservation to CDS from other organisms. The P. falciparum gene is located as a single copy on...

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Evaluation of immunogenicity and protective efficacy of carrier-free Plasmodium falciparum R23 antigen in pre-exposed Saimiri sciureus monkeys

Ronald Perraut, Sheny Morales-Betoulle, Cécile Le Scanf, Eliane Bourreau, more

Vaccine > 2000 > 19 > 1 > 59-67

We have reported previously that the recombinant Glutathione S-transferase GTR23, induced protection after immunisation of naive or previously exposed Saimiri monkeys. We investigated the immunogenicity of carrier-free R23 repeats in pre-exposed animals in two adjuvant formulations. Three of five monkeys immunised with alum-formulated repeats and one of two animals immunised with the Polyalphaolefine...

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Characterisation of the binding sites of monoclonal antibodies reacting with the Plasmodium falciparum rhoptry protein RhopH3

Jean-Claude Doury, Jean-Louis Goasdoue, Hugues Tolou, Maryse Martelloni, more

Molecular & Biochemical Parasitology > 1997 > 85 > 2 > 149-159

Twenty one mouse monoclonal antibodies reacting or cross-reacting with the Plasmodium falciparum RhopH3 protein reacted with Ag44, a recombinant antigen expressing the 134 C-terminal RhopH3 residues. Using overlapping peptides scanning this region, two major binding sites were identified. The first one, recognised by eight anti-RhopH3 and seven cross-reacting mAbs, was mapped to the sequence Thr Asp...

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Search results for: Serge Bonnefoy

Redistribution of FLAgellar Member 8 during the trypanosome life cycle: Consequences for cell fate prediction

Immunoglobulin response to Plasmodium falciparum RESA proteins in uncomplicated and severe malaria

Deconstructing Export of Malaria Proteins

A 24 bp cis-acting element essential for the transcriptional activity of Plasmodium falciparum CDP-diacylglycerol synthase gene promoter

Characterization of Plasmodium falciparum CDP-diacylglycerol synthase, a proteolytically cleaved enzyme

Evaluation of immunogenicity and protective efficacy of carrier-free Plasmodium falciparum R23 antigen in pre-exposed Saimiri sciureus monkeys

Characterisation of the binding sites of monoclonal antibodies reacting with the Plasmodium falciparum rhoptry protein RhopH3

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