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Background: Urokinase (uPA) and the urokinase receptor (uPAR) form a multifunctional system capable of concurrently regulating pericellular proteolysis, cell-surface adhesion, and mitogenesis. The role of uPA and uPAR in directed proteolysis is well established and its function in cellular adhesiveness has recently been clarified by numerous studies. The molecular mechanisms underlying the mitogenic...
The binding of urokinase-type plasminogen activator (uPA) to vascular smooth muscle cells (VSMCs) via its specific receptor (uPAR), facilitates cell migration, invasion, and matrix degradation, which are key events in atherosclerosis. These mechanisms are induced via intracellular signaling; however, the signaling cascade of the uPA receptor in VSMCs is incompletely understood. We investigated intracellular...
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