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Large porous particles are becoming increasingly popular as carriers for pulmonary drug delivery with both local and systemic applications. These particles have high geometric diameters (5–30μm) but low bulk density (~0.1g/cm3 or less) such that the aerodynamic diameter remains low (1–5μm). In this study salbutamol and budesonide serve as model inhalable drugs with poor water solubility. A novel method...