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A limiting barrier for mucosal absorption of drugs is the tight junction (TJ). TJs exist between two adjacent cells (bicellular TJ, bTJ) and at the sites where three cells meet (tricellular TJ, tTJ). We present a novel approach which employs a physiologically regulated pathway for the passage of large molecules through the tTJ. Main barrier-relevant tTJ proteins are tricellulin and angulin-1 to -3...
We have introduced a packaging technology utilizing high-dielectric ultra thin film between power and ground planes not as an embedded capacitor but a low impedance power distribution route directly connected to the chip. In this study the Power Distribution Network (PDN) characteristics of this structure were analyzed in detail using 3-d electromagnetic modeling in order to evaluate the feasibility...
A packaging strategy utilizes high-dielectric ultra thin film between power and ground planes is presented. High-dielectric ultra thin film between power and ground planes is used not as an embedded capacitor but a low impedance power distribution route directly connected to the chip. The package has a ground plane in the uppermost layer and power plane in the next metal layer in order to eliminate...
We have reported that human protein disulfide isomerase-related protein (hPDIR) has isomerase and chaperone activities that are lower than those of the human protein disulfide isomerase (hPDI), and that the b domain of hPDIR is critical for its chaperone activity [J. Biol. Chem. 279 (2004) 4604]. To investigate the basis of the differences between hPDI and hPDIR, and to determine the functions of...
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