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This paper describes a cocaine sensing using a membrane protein channel integrated in a microfluidic device (Figure 1). Protein channel (1.5 nm dia.) was reconstituted in planar lipid bilayers (BLMs) spanning at nanometer-sized parylene nanopore (400 nm dia., Figure 1b). DNA dissolved in solution can be driven through an alpha-hemolysin (αHL) channel by an applied electric field (Figure 1c left),...
This paper describes an integrated bio-reaction platform composed of silicon nanotweezers and open microfluidics for real time biomechanical assays. The silicon nanotweezers can sense slight biological modification of the trapped sample due to stable frequency response with high Q factor in liquid. The microfluidic device integrates active valves for controlling the biological medium. Biomolecular...
This paper demonstrates the real-time sensing of enzymatic reactions on a DNA bundle trapped by silicon nanotweezers. The digestion of DNA in protein solution (Hind III) is monitored by tracking the change in frequency response of the immersed tweezers. This new direct biomechanical detection clears the way for systematic bio tests at the molecular level by an integrated MEMS device.
We present a continuous glucose monitoring sensors using glucose-sensitive fluorescent dyes. We prepared microgels by copolymerizing acrylamide with the glucose sensitive fluorescent dyes. This fluorescent gel shows a high quantifiability and rapid response in the physiological glucose concentration range of 62.5 to 1000 mg/dL. Our in vivo study revealed that fluorescent intensity of the gels changed...
This study describes a membrane-protein based odorant sensor device consisting of microfluidic channels and frog eggs (Xenopus laevis oocyte) expressing olfactory receptors. These receptors are from silkmoth's receptors, BmOR1 and BmOR3 excited by specific pheromones, bombykol and bombykal, respectively. We employ a conventional two electrode voltage clamp method for the signal measurement of the...
This work is motivated by the need for accurate positioning of both adherent and non-adherent cells into arrays that can be integrated with microfluidic channels in high-throughput screening (HTS) for drug discovery. We describe a microfluidic device that allows rapid production of uniform micro hydrogel capsules that can contain cells. Up to 1times104 hydrogel capsules can be simply formed and arrayed...
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