Search results for: Yang Jee Kim

Items from 1 to 12 out of 12 results

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LINE‐1 hypomethylation is associated with radiation‐induced genomic instability in industrial radiographers

Yoon Hee Cho, Yoonhee Jang, Hae Dong Woo, Yang Jee Kim, more

Environmental and Molecular Mutagenesis > 60 > 2 > 174 - 184

Global DNA hypomethylation is proposed as a potential biomarker for cancer risk associated with genomic instability, which is an important factor in radiation‐induced cancer. However, the associations among radiation exposure, changes in DNA methylation, and carcinogenesis are unclear. The aims of this study were (1) to examine whether low‐level occupational radiation exposure induces genomic DNA...

article

Prenatal environmental tobacco smoke exposure increases allergic asthma risk with methylation changes in mice

Sonja Christensen, Zeina Jaffar, Elizabeth Cole, Virginia Porter, more

Environmental and Molecular Mutagenesis > 58 > 6 > 423 - 433

Allergic asthma remains an inadequately understood disease. In utero exposure to environmental tobacco smoke (ETS) has been identified as an environmental exposure that can increase an individual's asthma risk. To improve our understanding of asthma onset and development, we examined the effect of in utero ETS exposure on allergic disease susceptibility in an asthmatic phenotype using a house dust...

article

Enhancement of cisplatin cytotoxicity by benzyl isothiocyanate in HL-60 cells

Younghyun Lee, Yang Jee Kim, Young Joo Choi, Joong Won Lee, more

Food and Chemical Toxicology > 2012 > 50 > 7 > 2397-2406

Cis-diamminedichloroplatinum (II) (cisplatin) is one of the most widely used chemotherapeutic drugs, but its effectiveness is limited by tumor cell resistance and the severe side effects it causes. One strategy for overcoming this problem is the concomitant use of natural dietary compounds as therapeutic agents. Benzyl isothiocyanate (BITC) is a promising chemopreventive agent found in cruciferous...

article

Genotoxic effects of 3 T magnetic resonance imaging in cultured human lymphocytes

Joong Won Lee, Myeong Seong Kim, Yang Jee Kim, Young Joo Choi, more

Bioelectromagnetics > 32 > 7 > 535 - 542

The clinical and preclinical use of high‐field intensity (HF, 3 T and above) magnetic resonance imaging (MRI) scanners have significantly increased in the past few years. However, potential health risks are implied in the MRI and especially HF MRI environment due to high‐static magnetic fields, fast gradient magnetic fields, and strong radiofrequency electromagnetic fields. In this study, the genotoxic...

article

Micronucleus-centromere assay and DNA repair gene polymorphism in lymphocytes of industrial radiographers

Yoon Hee Cho, Yang Jee Kim, You Sun An, Hae Dong Woo, more

Mutation Research - Genetic Toxicology and Environmental Mutagenesis > 2009 > 680 > 1-2 > 17-24

The micronucleus-centromere assay using a pan-centromeric probe was used to assess chromosomal damage in lymphocytes of 47 industrial radiographers occupationally exposed to low dose ionizing radiation and 47 controls. The influence of genotype of DNA repair genes (XRCC1 ³⁹⁹ , XRCC3 ²⁴¹ and XPD ⁷⁵¹ ) on micronuclei (MN) frequency was also investigated. Centromere negative micronuclei...

article

Quercetin prevents necrotic cell death induced by co-exposure to benzo(a)pyrene and UVA radiation

Hae Dong Woo, Byeong Mo Kim, Yang Jee Kim, Young Joon Lee, more

Toxicology in Vitro > 2008 > 22 > 8 > 1840-1845

The phototoxicity of low-energy ultraviolet radiation, such as UVA, can be enhanced by the presence of photosensitizing agents. Hence, co-exposure of cells to benzo[a]pyrene (BaP), a widespread environmental carcinogen and photosensitizing agent, and UVA may synergistically induce DNA damage. In this study, exposure of cells to various concentrations of BaP for 1h followed by UVA irradiation (2J/cm...

article

Cytotoxicity of honeybee (Apis mellifera) venom in normal human lymphocytes and HL-60 cells

Young Joon Lee, Su Jin Kang, Byeong Mo Kim, Yang Jee Kim, more

Chemico-Biological Interactions > 2007 > 169 > 3 > 189-197

Whole bee venom (BV) is used to treat inflammatory diseases in Korean traditional medicine. Various studies have demonstrated anti-inflammatory and anticancer effects of BV. The toxicity of individual components of BV has been widely studied, although few studies have reported on the toxicity of BV. We sought to evaluate the cytotoxicity of BV in normal human lymphocytes and HL-60 cells. When cells...

article

Reoxygenation following hypoxia activates DNA-damage checkpoint signaling pathways that suppress cell-cycle progression in cultured human lymphocytes

Byeong-Mo Kim, Jun Yeol Choi, Yang-Jee Kim, Hae-Dong Woo, more

FEBS Letters > 2007 > 581 > 16 > 3005-3012

Cellular responses to DNA damage after hypoxia and reoxygenation (H/R) were examined in human lymphocytes. Cultured lymphocytes exposed to H/R showed a lower cytokinesis block proliferation index and a higher frequency of micronuclei in comparison to control cells. Western blots showed that H/R exposure induced p53 expression; however, p21 and Bax expression did not increase, indicating that H/R did...

article

Desferrioxamine (DFX) has genotoxic effects on cultured human lymphocytes and induces the p53-mediated damage response

Byeong Mo Kim, Jun Yeol Choi, Yang Jee Kim, Hae Dong Woo, more

Toxicology > 2007 > 229 > 3 > 226-235

Desferrioxamine (DFX), which is an iron chelator, mimics hypoxia by enhancing HIF1-α accumulation and upregulating inflammatory mediators. DFX is usually beneficial, with preventive effects related primarily to its ability to scavenge reactive oxygen species. However, toxic effects on skeletal and ocular organs have been reported. The cytokinesis block micronucleus test and alkaline single-cell gel...

article

Hypoxia/reoxygenation-induced cytotoxicity in cultured human lymphocytes

Jun Yeol Choi, Byeong Mo Kim, Yang Jee Kim, Hae Dong Woo, more

Biochemical and Biophysical Research Communications > 2007 > 352 > 2 > 366-371

Reactive oxygen species (ROS) generated after exposure to hypoxia and reoxygenation (H/R) play a pivotal role in the stimulation of cell death. In this study, we explored H/R-induced cytotoxicity in human lymphocytes. Compared to cells under normoxic conditions, H/R-treated cells exhibited significantly decreased viability and increased DNA breakage. Western blotting analysis demonstrated that H/R-induced...

article

Association of ALDH2 polymorphism with sensitivity to acetaldehyde-induced micronuclei and facial flushing after alcohol intake

Jin Sik Kim, Yang Jee Kim, Tae Yon Kim, Joo Young Song, more

Toxicology > 2005 > 210 > 2-3 > 169-174

To investigate whether sensitivity to the induction of micronuclei by acetaldehyde is associated with genetic polymorphisms of the aldehyde dehydrogenase-2 (ALDH2) gene, cytokinesis-block micronucleus (CBMN) assays were performed on peripheral lymphocytes from 47 healthy human subjects exposed to acetaldehyde in vitro. Facial flushing following alcohol intake was analyzed to determine if it was correlated...

article

The selective effect of genistein on the toxicity of bleomycin in normal lymphocytes and HL-60 cells

Rami Lee, Yang Jee Kim, Young Joon Lee, Hai Won Chung

Toxicology > 2004 > 195 > 2-3 > 87-95

This study was carried out to find whether genistein might enhance bleomycin induced cytotoxicity in human leukemia (HL-60) while protecting normal blood lymphocytes. Despite the excellent chemotherapeutic effect of bleomycin, its cytotoxicity and genotoxicity in normal cells remains a major problem in chemotherapy.Genistein, one of the major Soy isoflavones, is particularly effective in quenching...

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