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ZBTB7A, a transcription factor containing a tandem array of four Cys2‐His2 zinc fingers (ZFs), is vital for multiple physiological events through directional binding to different genomic loci. Our previously determined crystal structure of ZBTB7A in complex with a GCCCCTTCCCC sequence revealed that all four ZFs (ZF1–4) are involved in binding to γ‐globin −200 gene element to repress fetal haemoglobin...
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