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Regulatory T cells (T Reg ), CD4 + CD25 + FOXP3 + , are implicated in suppressing tumor immune responses. We analyzed peripheral blood lymphocytes (PBL) from breast cancer patients receiving a modified HLA class II HER2/neu peptide (AE37) vaccine for T Reg cells and correlated their levels with vaccine-specific immune responses. The mean CD4 + CD25 ...
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