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A meta‐analysis was performed to assess the association of the human leukocyte antigen‐G (HLA‐G) 14 bp insertion (ins)/deletion (del) polymorphism with unexplained recurrent spontaneous abortions (URSA). The fixed or random effect pooled measure was selected based on the homogeneity test among studies that was evaluated with I2. Odds ratio (OR) with 95% confidence interval (CI) was used to assess...
Folding around a peptide ligand is integral to the antigen presentation function of major histocompatibility complex (MHC) class I molecules. Several lines of evidence indicate that the broadly cross‐reactive 34‐1‐2 antibody is sensitive to folding of the MHC class I peptide‐binding groove. Here, we show that peptide‐loading complex proteins associated with the murine MHC class I molecule Kd are found...
The human leukocyte antigen G (HLA‐G) molecule, a non‐classical major histocompatibility complex class I antigen, exhibits highly limited tissue distribution and gene variation. Recent studies indicate strong immunoinhibitory properties in tumor cells that may favor their escape from anti‐tumor immune responses. However, the role of HLA‐G in cervical premalignant and malignant lesions has not been...
Keloids are common abnormal raised fibroproliferative lesions that can occur following even minor cutaneous trauma. There is strong evidence suggesting a genetic susceptibility in individuals affected by keloids including familial heritability, common occurrence in twins, and high prevalence in certain ethnic populations. Human leukocyte antigens (HLAs) have been proposed to modulate the immune response...
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