Search results for: Giorgio Raimondi

Items from 1 to 12 out of 12 results

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A short course of tofacitinib sustains the immunoregulatory effect of CTLA4‐Ig in the presence of inflammatory cytokines and promotes long‐term survival of murine cardiac allografts

Marcos Iglesias, Saami Khalifian, Byoung C. Oh, Yichuan Zhang, more

American Journal of Transplantation > 21 > 8 > 2675 - 2687

Costimulation blockade‐based regimens are a promising strategy for management of transplant recipients. However, maintenance immunosuppression via CTLA4‐Ig monotherapy is characterized by high frequency of rejection episodes. Recent evidence suggests that inflammatory cytokines contribute to alloreactive T cell activation in a CD28‐independent manner, a reasonable contributor to the limited efficacy...

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Multiphase Assembly of Small Molecule Microcrystalline Peptide Hydrogel Allows Immunomodulatory Combination Therapy for Long‐Term Heart Transplant Survival

Poulami Majumder, Yichuan Zhang, Marcos Iglesias, Lixin Fan, more

Small > 16 > 38 > n/a - n/a

Combination therapies that target multiple pathways involved in immune rejection of transplants hold promise for patients in need of restorative surgery. Herein, a noninteracting multiphase molecular assembly approach is developed to crystallize tofacitinib, a potent JAK1/3 inhibitor, within a shear‐thinning self‐assembled fibrillar peptide hydrogel network. The resulting microcrystalline tofacitinib...

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A computational model for microcirculation including Fahraeus‐Lindqvist effect, plasma skimming and fluid exchange with the tissue interstitium

Luca Possenti, Simone Gregorio, Fannie Maria Gerosa, Giorgio Raimondi, more

International Journal for Numerical Methods in Biomedical Engineering > 35 > 3 > n/a - n/a

We present a two‐phase model for microcirculation that describes the interaction of plasma with red blood cells. The model takes into account of typical effects characterizing the microcirculation, such as the Fahraeus‐Lindqvist effect and plasma skimming. Besides these features, the model describes the interaction of capillaries with the surrounding tissue. More precisely, the model accounts for...

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The outstanding questions in transplantation: It's about time…

Jamil Azzi, Giorgio Raimondi, Valeria Mas, Leonardo V. Riella, more

American Journal of Transplantation > 18 > 1 > 271 - 272

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Donor age negatively affects the immunoregulatory properties of both adipose and bone marrow derived mesenchymal stem cells

Lehao W. Wu, Yen-Ling Wang, Joani M. Christensen, Saami Khalifian, more

Transplant Immunology > 2014 > 30 > 4 > 122-127

Age negatively impacts the biologic features of mesenchymal stem cells (MSCs), including decreased expansion kinetics and differentiation potential. Clinically, donor-age may be within a wide spectrum; therefore, investigation of the role of donor's age on immunoregulatory potential is of critical importance to translate stem cell therapies from bench to bedside.Adipose and bone marrow derived MSCs...

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Bioinspired Controlled Release of CCL22 Recruits Regulatory T Cells In Vivo

Siddharth Jhunjhunwala, Giorgio Raimondi, Andrew J. Glowacki, Sherri J. Hall, more

Advanced Materials > 24 > 35 > 4735 - 4738

A rationally designed controlled‐release system is developed to recruit suppressive immune cells to specific sites in vivo. Continuous and sustained release of the chemokine CCL22 is achieved by fabricating porous polymeric microspheres. Application of these porous particles in vivo, in mice, leads to local regulatory T cell recruitment as well as a delay in rejection responses against transplanted...

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Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells

Siddharth Jhunjhunwala, Stephen C. Balmert, Giorgio Raimondi, Eefje Dons, more

Journal of Controlled Release > 2012 > 159 > 1 > 78-84

The absence of regulatory T cells (Treg) is a hallmark for a wide variety of disorders such as autoimmunity, dermatitis, periodontitis and even transplant rejection. A potential treatment option for these disorders is to increase local Treg numbers. Enhancing local numbers of Treg through in situ Treg expansion or induction could be a potential treatment option for these disorders. Current methods...

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Induced regulatory T cells: mechanisms of conversion and suppressive potential

Eefje M. Dons, Giorgio Raimondi, David K.C. Cooper, Angus W. Thomson

Human Immunology > 2012 > 73 > 4 > 328-334

Thymus-derived, naturally occurring CD4 ⁺ Forkhead Box P3 ⁺ regulatory T cells (nTreg) have suppressive activity that is important for the establishment and maintenance of immune homeostasis in the healthy state. Abundant reports have demonstrated that they can suppress pathogenic processes in autoimmune diseases and inhibit transplant rejection and graft-versus-host disease. Far less...

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Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells

Daisuke Tokita, Tina L. Sumpter, Giorgio Raimondi, Alan F. Zahorchak, more

Journal of Hepatology > 2008 > 49 > 6 > 1008-1018

The liver is comparatively rich in plasmacytoid (p) dendritic cells (DC), – innate immune effector cells that are also thought to play key roles in the induction and regulation of adaptive immunity.Liver and spleen pDC were purified from fms-like tyrosine kinase ligand-treated control or lipopolysaccharide-injected C57BL/10 mice. Flow cytometric and molecular biologic assays were used to characterize...

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Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion

Elaine K. Horibe, Justin Sacks, Jignesh Unadkat, Giorgio Raimondi, more

Transplant Immunology > 2008 > 18 > 4 > 307-318

Clinically-applicable protocols that promote tolerance to vascularized skin grafts may contribute to more widespread use of composite tissue transplantation. We compared the properties of alloantigen (Ag)-pulsed, rapamycin (Rapa)-conditioned and control bone marrow-derived host myeloid dendritic cells (DCs) and their potential, together with transient immunosuppression (anti-lymphocyte serum+cyclosporine),...