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L’insuline basale LY2605541 (LY) est une insuline lispro PEGylée qui a une grande taille hydrodynamique, ce qui ralentit l’absorption de l’insuline et diminue sa clairance, aboutissant ainsi à une durée d’action prolongée.Cette étude ouverte d’escalade de doses avec groupes parallèles a évalué la PK et la PD après administration de doses multiples. Des doses fixes de LY (3–9nmol/kg) ont été administrées...
This paper compares battery electric vehicles (BEV) to hydrogen fuel cell electric vehicles (FCEV) and hydrogen fuel cell plug-in hybrid vehicles (FCHEV). Qualitative comparisons of technologies and infrastructural requirements, and quantitative comparisons of the lifecycle cost of the powertrain over 100,000mile are undertaken, accounting for capital and fuel costs. A common vehicle platform is assumed...
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