Search results for: Markus Khalil

Items from 1 to 20 out of 24 results

article

Severe heart failure and the need for mechanical circulatory support and heart transplantation in pediatric patients with myocarditis: Results from the prospective multicenter registry “MYKKE”

Stephan Schubert, Bernd Opgen‐Rhein, Martin Boehne, Annika Weigelt, more

Pediatric Transplantation > 23 > 7 > n/a - n/a

Myocarditis represents an important cause for acute heart failure. MYKKE, a prospective multicenter registry of pediatric patients with myocarditis, aims to gain knowledge on courses, diagnostics, and therapy of pediatric myocarditis. The role of mechanical circulatory support (MCS) in children with severe heart failure and myocarditis is unclear. The aim of this study was to determine characteristics...

article

Effect and safety of treatment with ACE-inhibitor Enalapril and β-blocker metoprolol on the onset of left ventricular dysfunction in Duchenne muscular dystrophy - a randomized, double-blind, placebo-controlled trial

Sven Dittrich, Erika Graf, Regina Trollmann, Ulrich Neudorf, more

Orphanet Journal of Rare Diseases > 2019 > 14 > 1 > 1-13

Background X-linked Duchenne muscular dystrophy (DMD), the most frequent human hereditary skeletal muscle myopathy, inevitably leads to progressive dilated cardiomyopathy. We assessed the effect and safety of a combined treatment with the ACE-inhibitor enalapril and the β-blocker metoprolol in a German cohort of infantile and juvenile DMD patients with preserved left ventricular function. Methods...

article

Neonatal myocardial infarction: substantial improvement of cardiac function after autologous bone marrow-derived cell therapy

Martin Zschirnt, Christian Jux, Halvard Boenig, Andreas Zeiher, more

Clinical Research in Cardiology > 2019 > 108 > 11 > 1309-1311

Electronic supplementary material The online version of this article ( https://doi.org/10.1007/s00392-019-01478-y ) contains supplementary material, which is available to authorized users.

article

Creation of a restrictive atrial communication in heart failure with preserved and mid-range ejection fraction: effective palliation of left atrial hypertension and pulmonary congestion

Anna Bauer, Markus Khalil, Monika Lüdemann, Jürgen Bauer, more

Clinical Research in Cardiology > 2018 > 107 > 9 > 845-857

Background Left atrial decompression is considered in patients with symptomatic heart failure with preserved ejection fraction (HFpEF). We aimed to evaluate the feasibility and efficacy of transcatheter generation of a restrictive atrial septum communication to manage HFpEF from infancy to adulthood with cardiomyopathy and congenital heart defect. Methods and results From June 2009 to December 2016,...

article

Percutaneous pulmonary valve implantation for reconstruction of a patch‐repaired right ventricular outflow tract

Anoosh Esmaeili, Simone Bollmann, Markus Khalil, Roberta De Rosa, more

Journal of Interventional Cardiology > 31 > 1 > 106 - 111

Percutaneous pulmonary valve implantation (PPVI) is nowadays an accepted treatment option to repair post‐surgical conduit dysfunction of the right ventricular outflow tract (RVOT). In addition, many patients need a pulmonary valve to reconstruct a hemodynamically incompetent native or conduit free outflow tract. Based on our experience with percutaneous stent‐valve placement in a cohort of 125 patients,...

article

The Need to Define Treatment Goals for Protein-Losing Enteropathy in Fontan Care and Research

Kim ten Dam, Ingo Germund, Markus Khalil, Willem A. Helbing, more

Journal of the American College of Cardiology > 2017 > 70 > 20 > 2602-2603

article

Surgical-Interventional Hybrid Concept in a Newborn With Borderline Left Heart

Stefan Rupp, Josef Thul, Kerstin Gummel, Markus Khalil, more

The Annals of Thoracic Surgery > 2017 > 104 > 1 > e71-e73

Through a series of complex surgical and interventional procedures including downsizing of an unrestricted atrial septal defect, aortic arch reconstruction, pulmonary artery banding, reversed Potts shunt, and Melody valve in a mitral position, biventricular conversion was successfully achieved in a patient with a distinct borderline left ventricle. By use of these interventional steps, flow-mediated...

article

Toward evidence-based diagnosis of myocarditis in children and adolescents: Rationale, design, and first baseline data of MYKKE, a multicenter registry and study platform

Daniel R. Messroghli, Thomas Pickardt, Marcus Fischer, Bernd Opgen-Rhein, more

American Heart Journal > 2017 > 187 > C > 133-144

The aim of this registry is to provide data on age-related clinical features of suspected myocarditis and to create a study platform allowing for deriving diagnostic criteria and, at a later stage, testing therapeutic interventions in patients with myocarditis.After an initial 6-month pilot phase, MYKKE was opened in June 2014 as a prospective multicenter registry for patients from pediatric heart...

article

Prenatal diagnosis of functionally univentricular heart, associations and perinatal outcomes

Aline Wolter, Sina Nosbüsch, Andreea Kawecki, Jan Degenhardt, more

Prenatal Diagnosis > 36 > 6 > 545 - 554

Objective Functionally univentricular hearts (UVHs) represent cardiac anomalies in which either the pulmonary or systemic circulation cannot be supported independently. The purpose of our study was to determine perinatal outcomes after prenatal diagnosis of functionally UVH. Methods We retrospectively evaluated patients who presented between 2008 and June 2015 in our centre and in prenatal practice...

article

Focal myocardial fibrosis assessed by late gadolinium enhancement cardiovascular magnetic resonance in children and adolescents with dilated cardiomyopathy

Heiner Latus, Kerstin Gummel, Karin Klingel, Axel Moysich, more

Journal of Cardiovascular Magnetic Resonance > 2015 > 17 > 1 > 1-11

Background Different patterns of late gadolinium enhancement (LGE) including mid-wall fibrosis using cardiovascular magnetic resonance (CMR) have been reported in adult patients presenting with non-ischemic dilated cardiomyopathy (DCM). In these studies, LGE was associated with pronounced LV remodelling and predicted adverse cardiac outcomes. Accordingly, the purpose of our study was to determine...

article

The influence of physiological matrix conditions on permanent culture of induced pluripotent stem cell-derived cardiomyocytes

Carlos O. Heras-Bautista, Alisa Katsen-Globa, Nils E. Schloerer, Sabine Dieluweit, more

Biomaterials > 2014 > 35 > 26 > 7374-7385

Cardiomyocytes (CMs) from induced pluripotent stem (iPS) cells mark an important achievement in the development of in vitro pharmacological, toxicological and developmental assays and in the establishment of protocols for cardiac cell replacement therapy. Using CMs generated from murine embryonic stem cells and iPS cells we found increased cell–matrix interaction and more matured embryoid body (EB)...

article

Evidence for self-maintaining pluripotent murine stem cells in embryoid bodies

Wael A. Attia, Osama M. Abd El Aziz, Dimitry Spitkovsky, John A. Gaspar, more

Stem Cell Reviews and Reports > 2014 > 10 > 1 > 1-15

Pluripotent stem cells have great potential for regenerative medicine; however, their clinical use is associated with a risk of tumor formation. We utilized pluripotent cells expressing green fluorescent protein and puromycin resistance under control of the Oct4 promoter to study the persistence of potential pluripotent cells under embryoid body (EB) culture conditions, which are commonly used to...

article

Does reversed apical or basal left ventricular rotation in children with dilated cardiomyopathy recover following medical therapy? A two-dimensional speckle tracking study

Floris E.A. Udink ten Cate, Stephane R.W. Lorenz, Markus Khalil, Beate E. Schmidt, more

International Journal of Cardiology > 2011 > 153 > 3 > 330-333

article

Ablation strategies in a patient with Belhassen tachycardia

Mathias Emmel, Nayaranswami Sreeram, Markus Khalil, Roland Adelmann, more

Journal of Electrocardiology > 2011 > 44 > 6 > 802-805

The verapamil-sensitive Belhassen tachycardia is a ventricular reentrant tachycardia, involving left-sided Purkinje fibers and abnormal Purkinje or myocardial tissue. Ablation is feasible, targeting a diastolic fascicular potential in the apical left ventricle.We report on a 13-year-old girl with left posterior fascicular ventricular tachycardia. Tachycardia stopped during ablation, targeting a left-sided...

article

Influence of cocultivation with vital and ischemic ventricular tissue on electrophysiological properties of embryonic stem cell–derived cardiomyocytes

Rewa Nazzal, Marcel Halbach, Markus Khalil, Tobias Hannes, more

Journal of Electrocardiology > 2010 > 43 > 6 > 646-647

article

Biophysical characterization of KCNQ1 P320 mutations linked to long QT syndrome 1

Dierk Thomas, Markus Khalil, Markus Alter, Patrick A. Schweizer, more

Journal of Molecular and Cellular Cardiology > 2010 > 48 > 1 > 230-237

Hereditary long QT syndrome (LQTS) is a cardiovascular disorder characterized by prolongation of the QT interval on the surface ECG and a high risk for arrhythmia-related sudden death. Mutations in a cardiac voltage-gated potassium channel, KCNQ1, account for the most common form of LQTS, LQTS1. The objective of this study was the characterization of a novel KCNQ1 mutation linked to LQTS. Electrophysiological...

article

Biological pacemakers: characterization in an in vitro coculture model

Tobias Hannes, Marcel Halbach, Rewa Nazzal, Lukas Frenzel, more

Journal of Electrocardiology > 2008 > 41 > 6 > 562-566

Biological pacemakers could be an alternative or complement to electronic pacemakers. Embryonic stem cells (ESCs) can be differentiated in vitro to spontaneously active cells. Although numerous studies show that ESC-derived cardiomyocytes (ESC-CMs) and other cell types are capable to exert pacemaker function in vivo, detailed analyses of pattern and safety of conduction on a tissue level are rare...

article

Replacement of valved right ventricular to pulmonary artery conduits: an observational study with focus on right ventricular geometry

Tsvetomir Loukanov, Christian Sebening, Wolfgang Springer, Markus Khalil, more

Clinical Research in Cardiology > 2008 > 97 > 3 > 169-175

Objective Timing of the operation for exchange of right ventricular (RV) to pulmonary artery (PA) conduits is a matter of considerable debate. We aimed to study the course of right ventricular dimension in patients undergoing conduit exchange. Patients and methods We retrospectively studied all patients who underwent implantation and or replacement of RV/PA conduits during the time period between...

chapter

Short-Term Heart Rate Variability Response to Head-Up Tilt in Young Syncope Patients and Controls with Respect to Age

Hartmut Dickhaus, Christoph Maier, Markus Khalil, Herbert Ulmer

2006 International Conference of the IEEE Engineering in Medicine and Biology Society > Supplement > 6430 - 6433

Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society

This study aims at characterizing the short-term time-courses of time- and frequency-domain heart rate variability (HRV) parameters during head-up tilt test (HUTT). Data from 44 young patients with a history of syncope and 34 age-matched controls was analysed in two age-groups related to puberty (??13 and ?? 14 years), and separately for gender, by extracting minute-by-minute progression of mean RR-interval,...

chapter

Short-Term Heart Rate Variability Response to Head-Up Tilt in Young Syncope Patients and Controls with Respect to Age

Hartmut Dickhaus, Christoph Maier, Markus Khalil, Herbert Ulmer

2006 International Conference of the IEEE Engineering in Medicine and Biology Society > 6430 - 6433

Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society

This study aims at characterizing the short-term time-courses of time- and frequency-domain heart rate variability (HRV) parameters during head-up tilt test (HUTT). Data from 44 young patients with a history of syncope and 34 age-matched controls was analysed in two age-groups related to puberty (<13 and >14 years), and separately for gender, by extracting minute-by-minute progression of mean...

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INFONA - science communication portal

Search results for: Markus Khalil

Severe heart failure and the need for mechanical circulatory support and heart transplantation in pediatric patients with myocarditis: Results from the prospective multicenter registry “MYKKE”

Effect and safety of treatment with ACE-inhibitor Enalapril and β-blocker metoprolol on the onset of left ventricular dysfunction in Duchenne muscular dystrophy - a randomized, double-blind, placebo-controlled trial

Neonatal myocardial infarction: substantial improvement of cardiac function after autologous bone marrow-derived cell therapy

Creation of a restrictive atrial communication in heart failure with preserved and mid-range ejection fraction: effective palliation of left atrial hypertension and pulmonary congestion

Percutaneous pulmonary valve implantation for reconstruction of a patch‐repaired right ventricular outflow tract

The Need to Define Treatment Goals for Protein-Losing Enteropathy in Fontan Care and Research

Surgical-Interventional Hybrid Concept in a Newborn With Borderline Left Heart

Toward evidence-based diagnosis of myocarditis in children and adolescents: Rationale, design, and first baseline data of MYKKE, a multicenter registry and study platform

Prenatal diagnosis of functionally univentricular heart, associations and perinatal outcomes

Focal myocardial fibrosis assessed by late gadolinium enhancement cardiovascular magnetic resonance in children and adolescents with dilated cardiomyopathy

The influence of physiological matrix conditions on permanent culture of induced pluripotent stem cell-derived cardiomyocytes

Evidence for self-maintaining pluripotent murine stem cells in embryoid bodies

Does reversed apical or basal left ventricular rotation in children with dilated cardiomyopathy recover following medical therapy? A two-dimensional speckle tracking study

Ablation strategies in a patient with Belhassen tachycardia

Influence of cocultivation with vital and ischemic ventricular tissue on electrophysiological properties of embryonic stem cell–derived cardiomyocytes

Biophysical characterization of KCNQ1 P320 mutations linked to long QT syndrome 1

Biological pacemakers: characterization in an in vitro coculture model

Replacement of valved right ventricular to pulmonary artery conduits: an observational study with focus on right ventricular geometry

Short-Term Heart Rate Variability Response to Head-Up Tilt in Young Syncope Patients and Controls with Respect to Age

Short-Term Heart Rate Variability Response to Head-Up Tilt in Young Syncope Patients and Controls with Respect to Age

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