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Thymulin injection into rats (20-150 ng) i.p. caused a significant reduction in both mechanical (paw pressure test) and thermal (hot plate and tail flick tests) nociceptive thresholds. Thymulin injection also doubled IL-1β level in the liver of these animals. Induced hyperalgesia was reversed completely by α-MSH related tripeptide, Lys-d-Pro-Val in low doses, which is known to antagonize IL-1β and...