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Chemotherapy in combination with radiation therapy has evolved over the last several decades as an important modality in the treatment of head and neck squamous cell carcinoma. Because of the effectiveness of chemoradiation therapy at controlling disease at the primary site, ablative surgery is generally reserved for surgical salvage if chemoradiation fails to control primary site disease. However,...
The aim of this study was to test the hypothesis that calretinin (CR) levels in the aged mouse auditory brainstem depend upon hearing ability. Old animals with good hearing, and thus higher sound-evoked activity levels, were predicted to have higher levels of CR immunoreactivity than old animals with hearing loss. CR immunoreactivity was analyzed in the deep layer (layer III) of the dorsal cochlear...
This study was conducted to test the hypothesis that age-related calretinin (CR) up-regulation seen in the dorsal cortex of the inferior colliculus (ICdc) of old hearing CBA mice is dependent upon neural activity within the auditory pathway. We tested this hypothesis by bilaterally deafening young CBA/CaJ mice with kanamycin, and then aging them until 24 months. This manipulation mimics the lack of...
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