Search results for: David H. Raulet

Items from 1 to 20 out of 36 results

article

Dysregulated cellular functions and cell stress pathways provide critical cues for activating and targeting natural killer cells to transformed and infected cells

David H. Raulet, Assaf Marcus, Laurent Coscoy

Immunological Reviews > 280 > 1 > 93 - 101

Natural killer (NK) cells recognize and kill cancer cells and infected cells by engaging cell surface ligands that are induced preferentially or exclusively on these cells. These ligands are recognized by activating receptors on NK cells, such as NKG2D. In addition to activation by cell surface ligands, the acquisition of optimal effector activity by NK cells is driven in vivo by cytokines and other...

article

Natural-Killer-like B Cells Display the Phenotypic and Functional Characteristics of Conventional B Cells

Yann M. Kerdiles, Francisca F. Almeida, Thornton Thompson, Michael Chopin, more

Immunity > 2017 > 47 > 2 > 199-200

article

An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway

Debojit Bose, Yichi Su, Assaf Marcus, David H. Raulet, more

Cell Chemical Biology > 2016 > 23 > 12 > 1539-1549

In mammalian cells, the second messenger (2′–5′,3′–5′) cyclic guanosine monophosphate-adenosine monophosphate (2′,3′-cGAMP), is produced by the cytosolic DNA sensor cGAMP synthase (cGAS), and subsequently bound by the stimulator of interferon genes (STING) to trigger interferon response. Thus, the cGAS-cGAMP-STING pathway plays a critical role in pathogen detection, as well as pathophysiological conditions...

article

Immunosurveillance and immunotherapy of tumors by innate immune cells

Alexandre Iannello, Thornton W Thompson, Michele Ardolino, Assaf Marcus, more

Current Opinion in Immunology > 2016 > 38 > C > 52-58

Increasing evidence supports a role for innate immune effector cells in tumor surveillance. Natural killer (NK) cells and myeloid cells represent the two main subsets of innate immune cells possessing efficient but quite different tumor suppressive abilities. Here, we describe the germline-encoded NK cell receptors that play a role in suppressing tumor development and describe briefly the cellular...

article

NK cell self tolerance, responsiveness and missing self recognition

Nataliya Shifrin, David H. Raulet, Michele Ardolino

Seminars in Immunology > 2014 > 26 > 2 > 138-144

Natural killer (NK) cells represent a first line of defense against pathogens and tumor cells. The activation of NK cells is regulated by the integration of signals deriving from activating and inhibitory receptors expressed on their surface. However, different NK cells respond differently to the same stimulus, be it target cells or agents that crosslink activating receptors. The processes that determine...

article

A selective role of NKG2D in inflammatory and autoimmune diseases

Nadia Guerra, Kathleen Pestal, Tiffany Juarez, Jennifer Beck, more

Clinical Immunology > 2013 > 149 > 3 Part B > 432-439

The NKG2D activating receptor has been implicated in numerous autoimmune diseases. We tested the role of NKG2D in models of autoimmunity and inflammation using NKG2D knockout mice and antibody blockade experiments. The severity of experimental autoimmune encephalitis (EAE) was decreased in NKG2D-deficient mice when the disease was induced with a limiting antigen dose, but unchanged with an optimal...

article

A simple and effective method for differentiating GFP and YFP by flow cytometry using the violet laser

Assaf Marcus, David H. Raulet

Cytometry Part A > 83A > 11 > 973 - 974

article

Evidence for Natural Killer Cell Memory

Assaf Marcus, David H. Raulet

Current Biology > 2013 > 23 > 17 > R817-R820

Natural killer (NK) cells are generally considered to be part of the innate immune system. Over the past few years, however, evidence has accumulated suggesting that NK cells have certain features that are characteristic of the adaptive immune system. NK cells reportedly respond in an antigen-specific manner to a variety of small molecules and certain viruses, and mediate enhanced responses to these...

article

Infection-Induced Regulation of Natural Killer Cells by Macrophages and Collagen at the Lymph Node Subcapsular Sinus

Janine L. Coombes, Seong-Ji Han, Nico van Rooijen, David H. Raulet, more

Cell Reports > 2012 > 2 > 1 > 124-135

Infection leads to heightened activation of natural killer (NK) cells, a process that likely involves direct cell-to-cell contact, but how this occurs in vivo is poorly understood. We have used two-photon laser-scanning microscopy in conjunction with Toxoplasma gondii mouse infection models to address this question. We found that after infection, NK cells accumulated in the subcapsular region of the...

article

Natural Killer Cells: Remembrances of Things Past

David H. Raulet

Current Biology > 2009 > 19 > 7 > R294-R296

Recent work has revealed that natural killer cells exhibit a form of memory, previously considered an exclusive property of adaptive immunity. While protective, natural killer cell memory is probably hazier and more fleeting than T cell memory.

article

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

Nadia Guerra, Ying Xim Tan, Nathalie T. Joncker, Augustine Choy, more

Immunity > 2008 > 28 > 5 > 723

article

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

Nadia Guerra, Ying Xim Tan, Nathalie T. Joncker, Augustine Choy, more

Immunity > 2008 > 28 > 4 > 571-580

Ligands for the NKG2D stimulatory receptor are frequently upregulated on tumor lines, rendering them sensitive to natural killer (NK) cells, but the role of NKG2D in tumor surveillance has not been addressed in spontaneous cancer models. Here, we provided the first characterization of NKG2D-deficient mice, including evidence that NKG2D was not necessary for NK cell development but was critical for...

article

DNA Mismanagement Leads to Immune System Oversight

Laurent Coscoy, David H. Raulet

Cell > 2007 > 131 > 5 > 836-838

Trex1, a major 3′ DNA exonuclease in mammalian cells, has been thought to act primarily in DNA replication or repair. Surprisingly, the major phenotype resulting from Trex1 deficiency in humans and mice is a chronic inflammatory disease. In this issue, Yang et al. (2007) report that Trex1 deficiency causes chronic activation of the ATM-dependent DNA-damage checkpoint and accumulation of a discrete...

article

Stromal-cell regulation of natural killer cell differentiation

Claude Roth, Carla Rothlin, Sylvain Riou, David H. Raulet, more

Journal of Molecular Medicine > 2007 > 85 > 10 > 1047-1056

Natural killer (NK) cells are bone-marrow-derived lymphocytes that play a crucial role in host defense against some viral and bacterial infections, as well as against tumors. Their phenotypic and functional maturation requires intimate interactions between the bone marrow stroma and committed precursors. In parallel to the identification of several phenotypic and functional stages of NK cell development,...

article

Missing self recognition and self tolerance of natural killer (NK) cells

David H. Raulet

Seminars in Immunology > 2006 > 18 > 3 > 145-150

Natural killer cells express inhibitory receptors specific for polymorphic MHC molecules, which enables them to mediate “missing self recognition”, the capacity to attack self cells that extinguish expression of MHC class I molecules. A key question is: how are NK cells rendered self-tolerant? It was proposed that all NK cells express at least one inhibitory receptor specific for self MHC, but we...

article

Coordinated Induction by IL15 of a TCR-Independent NKG2D Signaling Pathway Converts CTL into Lymphokine-Activated Killer Cells in Celiac Disease

Bertrand Meresse, Zhangguo Chen, Cezary Ciszewski, Maria Tretiakova, more

Immunity > 2004 > 21 > 3 > 357-366

A major function of NKG2D linking innate and adaptive immunity is to upregulate antigen-specific CTL-mediated cytotoxicity in tissues expressing stress-induced NKG2D ligands, such as MIC, by coactivating TCR signaling. Here, we show that, under conditions of dysregulated IL15 expression in vivo in patients with celiac disease and in vitro in healthy individuals, multiple steps of the NKG2D/DAP10 signaling...

article

Positive Selection of Dendritic Epidermal γδ T Cell Precursors in the Fetal Thymus Determines Expression of Skin-Homing Receptors

Na Xiong, Chuhlo Kang, David H Raulet

Immunity > 2004 > 21 > 1 > 121-131

The role of cellular selection in the development of γδ T cells remains unclear. Knockout mice lacking a subset of Vγ genes, including Vγ3, contain abundant γδ T cells but are devoid of dendritic epidermal γδT cells (DETCs), which normally express an invariant Vγ3/Vδ1 γδ TCR. A rearranged Vγ2 transgene restored DETC development, but the restored DETCs selectively expressed a unique Vδ gene other than...

article

Innate immune recognition by stimulatory immunoreceptors

Andreas Diefenbach, David H Raulet

Current Opinion in Immunology > 2003 > 15 > 1 > 37-44

The specificity of cells of the innate immune system is determined in part by various stimulatory receptors that function in different forms of immune recognition. NKG2D, a stimulatory receptor expressed by natural killer (NK) cells, macrophages and certain T cell subsets, recognizes various families of 'induced-self' ligands. The ligands are distantly related to class I MHC molecules and are induced...

article

The Role of the NKG2D Immunoreceptor in Immune Cell Activation and Natural Killing

Amanda M. Jamieson, Andreas Diefenbach, Christopher W. McMahon, Na Xiong, more

Immunity > 2002 > 17 > 1 > 19-29

Little is known concerning the stimulatory receptors responsible for tumor cell lysis by NK cells. We generated a monoclonal antibody specific for murine NKG2D in order to investigate its function. Blocking of NKG2D inhibited natural cytotoxicity of all tumor cells tested that express ligands for the receptor. Staining analysis showed that NKG2D is also expressed by activated CD8 ⁺ T cells...

article

Redundant and Unique Roles of Two Enhancer Elements in the TCRγ Locus in Gene Regulation and γδ T Cell Development

Na Xiong, Chulho Kang, David H. Raulet

Immunity > 2002 > 16 > 3 > 453-463

Many mammalian genes, including those encoding antigen receptors, contain more than one enhancer element. Deleting one element often does not prevent expression, but functional redundancy has never been directly demonstrated by gene targeting of multiple elements. We demonstrate that simultaneous deletion of two enhancer/LCR-like elements in the TCR Cγ1 cluster, HsA and 3'E _C _γ ₁ ,...

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Keywords

NATURAL KILLER CELLS (2)
ANERGY (1)
CANCER (1)
CD8 T CELLS (1)
CELL STRESS (1)
CELLIMMUNO (1)
CGAMP (1)
CGAS (1)
CGAS‐STING (1)
COMMITMENT (1)
CYCLIC AMP-GMP (1)
CYCLIC DINUCLEOTIDE (1)
CYCLIC GMP-AMP (1)
CYTOTOXIC (1)
DEVELOPMENT (1)
EAE (1)
GEMM-II (1)
HEMATOPOIESIS (1)
HIGH-THROUGHPUT SCREEN (1)
HYPORESPONSIVE (1)
IMMUNOLOGY (1)
INFECTIOUS DISEASE (1)
INFLAMMATION (1)
INHIBITION (1)
INTESTINAL INFLAMMATION (1)
KIR (1)
LY49 (1)
LYMPHOCYTE (1)
MHC CLASS I (1)
MISSING SELF (1)
NATURAL KILLER CELLS; CLASS I MOLECULES; CLASS I-DEFICIENCY; LY49; TOLERANCE (1)
NK CELL (1)
NK CELL EDUCATION (1)
NK CELL RECEPTOR (1)
NK CELLS (1)
NKG2A (1)
NKG2D (1)
NOD (1)
RIBOSWITCH (1)
SPINACH APTAMER (1)
STING (1)
STROMAL-CELL REGULATION (1)
T-CELL DEVELOPMENT (1)
T-CELL LINEAGE DECISION (1)
T-CELL RECEPTOR GENE EXPRESSION (1)
T-CELL RECEPTOR GENE REARRANGEMENT (1)
T-CELL RECEPTOR ΓΔ TRANSGENIC MICE (1)
TOLERANCE (1)
TOLL‐LIKE RECEPTORS/PATTERN RECOGNITION RECEPTORS (1)
TRANSCRIPTION FACTORS (1)
TYPE 1 DIABETES (1)
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Data set

Elsevier (33)
Wiley (2)
Springer (1)

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Search results for: David H. Raulet

Dysregulated cellular functions and cell stress pathways provide critical cues for activating and targeting natural killer cells to transformed and infected cells

Natural-Killer-like B Cells Display the Phenotypic and Functional Characteristics of Conventional B Cells

An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway

Immunosurveillance and immunotherapy of tumors by innate immune cells

NK cell self tolerance, responsiveness and missing self recognition

A selective role of NKG2D in inflammatory and autoimmune diseases

A simple and effective method for differentiating GFP and YFP by flow cytometry using the violet laser

Evidence for Natural Killer Cell Memory

Infection-Induced Regulation of Natural Killer Cells by Macrophages and Collagen at the Lymph Node Subcapsular Sinus

Natural Killer Cells: Remembrances of Things Past

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

DNA Mismanagement Leads to Immune System Oversight

Stromal-cell regulation of natural killer cell differentiation

Missing self recognition and self tolerance of natural killer (NK) cells

Coordinated Induction by IL15 of a TCR-Independent NKG2D Signaling Pathway Converts CTL into Lymphokine-Activated Killer Cells in Celiac Disease

Positive Selection of Dendritic Epidermal γδ T Cell Precursors in the Fetal Thymus Determines Expression of Skin-Homing Receptors

Innate immune recognition by stimulatory immunoreceptors

The Role of the NKG2D Immunoreceptor in Immune Cell Activation and Natural Killing

Redundant and Unique Roles of Two Enhancer Elements in the TCRγ Locus in Gene Regulation and γδ T Cell Development

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