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Prostaglandin E 2 (PGE 2 ) exerts diverse biological effects through four G-protein-coupled cell surface receptor subtypes, EP1–4. This study's objective was to characterize EP1–4 receptor mRNA expression within pregnant guinea pig myometrium during early implantation stage (gestation day [GD] 6) and late stage gestation (GD 50) and evaluate in vitro contractile activity of receptor...
Prostaglandin E 2 (PGE 2 ) exerts its biological effects through 4 different receptor subtypes, EP-1, EP-2, EP-3, and EP-4. Recently we have demonstrated the importance of the prostaglandin E 2 receptor subtype EP-2 in the healing of bone defects and fractures. This discovery led to the identification of CP-533,536, an EP-2 selective agonist, a promising therapeutic alternative...
The high prevalence of osteoporosis in postmenopausal women indicates that estrogen deficiency plays a major role in this disorder. Estrogen replacement therapy has been shown to prevent bone loss in these patients. In the laboratory the ovariectomized (Ovx) rat has been extensively used as a model to study the mechanism of bone loss in postmenopausal women. After Ovx in rats, there is a loss of...
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