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Transforming growth factors βs (TGFβs) are known to have important roles in neuronal survival and can be upregulated in disease. However, unlike many other trophic factors, nothing is known about the rapid neurotransmitter-like actions of TGFβ in the CNS. We explored this by examining the effects of TGFβ on calcium influx of large enzymatically dissociated basal forebrain neurons. We show that brief...