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Dolutegravir and Elvitegravir belongs to a class of integrase inhibitors which has recently been approved by the FDA for the treatment of HIV-infection. Elvitegravir and its co-administered booster drug, Cobicistat, has shown the potential to be a candidate for a one pill once a day regimen and is currently a component of many clinical trials. A sensitive LC–MS/MS method has been developed and validated...
The enrichment of substrates/surfaces with selected functional groups, methyl (–CH 3 ), allyl amine (–NH 2 ), allyl alcohol (–OH) and acrylic acid (–COOH), can be used to trigger mesenchymal stem (MSC) cell differentiation into specified lineages, minimising the need for exogenous biological supplementation. We present the successful translation of this research phenomenon to an injectable...
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