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Research on intrauterine growth restriction (IUGR) and subsequent development of obesity, type 2 diabetes and the metabolic syndrome is rapidly expanding, and potential implications for primary prevention are considerable. We have critically appraised one of the experimental animal models frequently used as mimic of human fetal growth restriction, which involves bilateral ligation of the uterine artery...
Mit der intrauterinen Prägung lebenslang anhaltender Krankheitsdispositionen beschäftigt sich eine vergleichsweise junge medizinische Teildisziplin, die als „Perinatale Programmierung“ international in zunehmendem Maß beachtet und akzeptiert wird. Für die Etablierung dieses neuen Wissenschaftsgebietes waren v. a. Langzeitbeobachtungen entscheidend, zum einen an Kindern von Müttern mit Diabetes mellitus...
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